LGK-974

Name: LGK-974
SKU: A12816
Price: 245 CNY
Rating: 5 (6 reviews)

目录号: A12816

PORCN 抑制剂

6 篇发表文献

LGK974 是一种高效、选择性强且口服生物利用度高的Porcupine抑制剂（Wnt信号拮抗剂），在Wnt信号报告基因检测和Porcupine结合检测中的IC50值均小于1 nM。

Skip to the end of the images gallery

Skip to the beginning of the images gallery

Grouped product items
规格	价格	库存
1mg	¥245.00	现货
2mg	¥350.00	现货
5mg	¥595.00	现货
10mg	¥1,015.00	现货
25mg	¥2,065.00	现货
50mg	¥3,815.00	现货
100mg	¥5,670.00	现货
*10mM 1mL in DMSO**	¥630.00	现货
更大包装	更多折扣

大包装询价

Notify me when the price drops

全国免运费, 顺丰次日达

重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用LGK-974发表的6篇文献

Uxia Gurriaran-Rodriguez, .et al. , Sci Adv, 2024, Dec 13;10(50):eado5914 PMID: 39661666

Sho Tsukamoto, .et al. , Development, 2023, Aug 1;150(15):dev201734 PMID: 37539462

Bopei Cui, .et al. , Signal Transduct Target Ther, 2023, Sep 25;8(1):366 PMID: 37743418

A-Ri Cho, .et al. , Sci Rep, 2022, Apr 29;12(1):7013 PMID: 35487932

Yang JM, .et al. , Toxicology, 2018, Dec 1;410:65-72 PMID: 30205152

E Lemieux, .et al. , Oncogene, 2015, Sep 17; 34(38): 4914-4927 PMID: 25500543

生物活性

Discription

LGK974 is a highly potent, selective and orally bioavailable Porcupine inhibitor (Wnt signaling antagonist) with an IC50 <1 nM in the Wnt signaling reporter assay and Porcupine binding assay.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A12816
分子式	C23H20N6O
分子量	396.44
CAS号	1243244-14-5
SMILES	CC1=C(N=CC(=C1)CC(=O)NC2=NC=C(C=C2)C3=NC=CN=C3)C4=CC(=NC=C4)C
其他名称	LGK974, LGK 974
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	Warmed: 76 mg/mL (191.7 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	2% DMSO+corn oil	4 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.22 mL	126.12 mL	252.24 mL
0.5 mM	5.04 mL	25.22 mL	50.45 mL
1 mM	2.52 mL	12.61 mL	25.22 mL
5 mM	0.5 mL	2.52 mL	5.04 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

Calculate Reset

* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Keywords: 购买 LGK-974 | LGK-974 供应商 | LGK-974 花费 | LGK-974 生产商 | 订购 LGK-974 | LGK-974 代理商 | 购买 1243244-14-5 | 1243244-14-5 供应商 | 1243244-14-5 花费 | 1243244-14-5 生产商 | 订购 1243244-14-5 | 1243244-14-5 代理商