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Lifirafenib (BGB-283) is a novel and potent Raf Kinase and EGFR inhibitor with IC50 values of 23 and 29 nM for recombinant BRafV600E and EGFR, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.9 mL | 104.51 mL | 209.02 mL |
| 0.5 mM | 4.18 mL | 20.9 mL | 41.8 mL |
| 1 mM | 2.09 mL | 10.45 mL | 20.9 mL |
| 5 mM | 0.42 mL | 2.09 mL | 4.18 mL |
*The above data is based on the productmolecular weight 478.42. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A20988 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 478.42 |
| Formula | C25H17F3N4O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1446090-77-2 |
| Synonyms | BGB-283, BGB283, BGB 283 |
| SMILES | FC(F)(F)C(C=C1)=CC2=C1N=C(N2)[C@@H]3[C@H]([C@@H]43)OC(C4=C5)=CC=C5OC6=CC=NC(N7)=C6CCC7=O |
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