LLY-283

Name: LLY-283
SKU: A19754
Price: 175 CNY
Rating: 5 (288 reviews)

目录号: A19754

PRMT5 抑制剂

LLY-283 是一种强效、选择性的口服 蛋白精氨酸甲基转移酶5 (PRMT5) 抑制剂，对 PRMT5:MEP50 复合体的 IC50 为 22 nM，Kd 为 6 nM，并显示出抗肿瘤活性。

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Grouped product items
规格	价格	库存
1mg	¥175.00	现货
5mg	¥490.00	现货
10mg	¥945.00	现货
50mg	¥2,835.00	现货
100mg	¥5,460.00	现货
*10mM 1mL in DMSO**	¥560.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

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生物活性

Discription

LLY-283 is a potent, selective and oral protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 22 nM and a Kd of 6 nM for PRMT5:MEP50 complex, and shows antitumor activity.

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A19754
分子式	C17H18N4O4
分子量	342.35
CAS号	2040291-27-6
SMILES	O[C@H]1[C@@H](O[C@@]([C@@H](C2=CC=CC=C2)O)([H])[C@H]1O)N3C4=NC=NC(N)=C4C=C3
其他名称	LLY283, LLY 283
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	64 mg/mL (186.94 mM)
	Water	5 mg/mL (14.6 mM)
	Ethanol	3 mg/mL (8.76 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	29.21 mL	146.05 mL	292.1 mL
0.5 mM	5.84 mL	29.21 mL	58.42 mL
1 mM	2.92 mL	14.6 mL	29.21 mL
5 mM	0.58 mL	2.92 mL	5.84 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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