LLY-283
目录号: A19754
PRMT5 inhibitor
LLY-283 是一种强效、选择性的口服 蛋白精氨酸甲基转移酶5 (PRMT5) 抑制剂,对 PRMT5:MEP50 复合体的 IC50 为 22 nM,Kd 为 6 nM,并显示出抗肿瘤活性。
Discription | LLY-283 is a potent, selective and oral protein arginine methyltransferase 5 (PRMT5) inhibitor, with an IC50 of 22 nM and a Kd of 6 nM for PRMT5:MEP50 complex, and shows antitumor activity. | |||||
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Cell Research |
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目录号 | A19754 |
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分子式 | C17H18N4O4 |
分子量 | 342.35 |
CAS号 | 2040291-27-6 |
SMILES | O[C@H]1[C@@H](O[C@@]([C@@H](C2=CC=CC=C2)O)([H])[C@H]1O)N3C4=NC=NC(N)=C4C=C3 |
其他名称 | LLY283, LLY 283 |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
In vitro | DMSO | 64 mg/mL (186.94 mM) | |
Water | 5 mg/mL (14.6 mM) | ||
Ethanol | 3 mg/mL (8.76 mM) | ||
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
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0.1 mM | 29.21 mL | 146.05 mL | 292.1 mL |
0.5 mM | 5.84 mL | 29.21 mL | 58.42 mL |
1 mM | 2.92 mL | 14.6 mL | 29.21 mL |
5 mM | 0.58 mL | 2.92 mL | 5.84 mL |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2