Lonafarnib (SCH66336)

Name: Lonafarnib (SCH66336)
SKU: A12328
Price: 245 CNY
Rating: 5 (1 reviews)

目录号: A12328

FPTase 抑制剂

1 篇发表文献

Lonafarnib（SCH 66336）是一种选择性的FPTase抑制剂，针对H-ras、K-ras-4B和N-ras，其IC50分别为1.9 nM、5.2 nM和2.8 nM。

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Grouped product items
规格	价格	库存
1mg	¥245.00	现货
5mg	¥595.00	现货
10mg	¥1,015.00	现货
25mg	¥1,925.00	现货
50mg	¥3,430.00	现货
100mg	¥4,795.00	现货
*10mM 1mL in DMSO**	¥1,218.00	现货
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Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用Lonafarnib (SCH66336)发表的1篇文献

Stella Liong, .et al. , Mediators Inflamm, 2018, 2018: 3645386 PMID: 30402038

生物活性

Discription

Lonafarnib (SCH 66336) is a selectively FPTase inhibitor for H-ras, K-ras-4B and N-ras with IC50 of 1.9 nM, 5.2 nM and 2.8 nM, respectively.

Targets

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Cell Research

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Cell Line	Type	Value	Description	References
Caco-2	CC50	10.71 μM	Toxicity against Caco-2 cells determined at 48 hours by intracellular ATP concentration using the CellTiter-Glo Luminescent Cell Viability Assay	10.21203/rs.3.rs-23951/v1
Caco-2	IC50	5.68 μM	Determination of IC50 values for inhibition of SARS-CoV-2 induced cytotoxicity of Caco-2 cells after 48 hours by high content imaging	10.21203/rs.3.rs-23951/v1

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产品信息

目录号	A12328
分子式	C27H31Br2ClN4O2
分子量	638.82
CAS号	193275-84-2
SMILES	C1CN(CCC1CC(=O)N2CCC(CC2)[C@@H]3C4=C(C=C(C=C4CCC5=CC(=CN=C35)Br)Cl)Br)C(=O)N
其他名称	Sarasar, SCH 66336, SCH66336, SCH-66336
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	116 mg/mL (181.58 mM)
	Water	Insoluble
	Ethanol	116 mg/mL (181.58 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	15.65 mL	78.27 mL	156.54 mL
0.5 mM	3.13 mL	15.65 mL	31.31 mL
1 mM	1.57 mL	7.83 mL	15.65 mL
5 mM	0.31 mL	1.57 mL	3.13 mL

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