Lonafarnib (SCH66336)

Name: Lonafarnib (SCH66336)
SKU: A12328

目录号: A12328

FPTase 抑制剂

Product Citations (1)

Lonafarnib (SCH66336) Chemical Structure

CAS NO. 193275-84-2

Lonafarnib (SCH66336)是H-ras、K-ras-4B和N-ras的选择性FPTase抑制剂，IC50分别为1.9 nM、5.2 nM和2.8 nM。

库存：现货

规格	价格	数量
5 mg	￥ 630.00
10 mg	￥ 1,050.00
25 mg	￥ 1,960.00
50 mg	￥ 3,500.00
10mM * 1mL in DMSO	￥ 1,218.00

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生物活性

Lonafarnib (SCH66336)是H-ras、K-ras-4B和N-ras的选择性FPTase抑制剂，IC50分别为1.9 nM、5.2 nM和2.8 nM。

靶点信息

H-ras (Cell-free assay)	N-ras (Cell-free assay)	K-ras-4B (Cell-free assay)
1.9 nM	2.8 nM	5.2 nM

溶解度 *

In vitro	DMSO	116 mg/mL (181.58 mM)
	Water	Insoluble
	Ethanol	116 mg/mL (181.58 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	15.65 mL	78.27 mL	156.54 mL
0.5 mM	3.13 mL	15.65 mL	31.31 mL
1 mM	1.57 mL	7.83 mL	15.65 mL
5 mM	0.31 mL	1.57 mL	3.13 mL

*The above data is based on the productmolecular weight 638.82. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A12328
作用机制	Inhibitor (抑制剂)
M. Wt	638.82
Formula	C27H31Br2ClN4O2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	193275-84-2
Synonyms	Sarasar, SCH 66336, SCH66336, SCH-66336
SMILES	C1CN(CCC1CC(=O)N2CCC(CC2)[C@@H]3C4=C(C=C(C=C4CCC5=CC(=CN=C35)Br)Cl)Br)C(=O)N