Loratadine
目录号: A10538
洛拉替定是一种非镇静性抗组胺药，能够抑制组胺诱导的内皮细胞中IL-6和IL-8的分泌。洛拉替定是一种选择性的外周组胺H1受体逆向激动剂，其IC50值大于32微摩尔。
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生物活性
| Discription | Loratadine is a non-sedative antihistamine that inhibits histamine-induced activities of IL-6 and IL-8 secretion in endothelial cells. Loratadine is a selective inverse peripheral histamine H1-receptor agonist with an IC50 of >32 μM. | |||||
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产品信息
| 目录号 | A10538 |
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| 分子式 | C22H23ClN2O2 |
| 分子量 | 382.39 |
| CAS号 | 79794-75-5 |
| SMILES | CCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1 |
| 其他名称 | Alavert, Claritin |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 15 mg/mL (39.18 mM) | |
| Water | Insoluble | ||
| Ethanol | 68 mg/mL (177.6 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.15 mL | 130.76 mL | 261.51 mL |
| 0.5 mM | 5.23 mL | 26.15 mL | 52.3 mL |
| 1 mM | 2.62 mL | 13.08 mL | 26.15 mL |
| 5 mM | 0.52 mL | 2.62 mL | 5.23 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 79794-75-5 | 79794-75-5 供应商 | 79794-75-5 花费 | 79794-75-5 生产商 | 订购 79794-75-5 | 79794-75-5 代理商