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Loratadine是一种非镇静抗组胺药，抑制组胺诱导的内皮细胞分泌IL-6和IL-8的活性。氯雷他定是一种选择性外周组胺h1受体拮抗剂，IC50 > 32 μM。
靶点信息
| H1 receptor | B(0)AT2 | |||
| N/A | 4 μM |
| In vitro | DMSO | 15 mg/mL (39.18 mM) | |
| Water | Insoluble | ||
| Ethanol | 68 mg/mL (177.6 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 26.15 mL | 130.76 mL | 261.51 mL |
| 0.5 mM | 5.23 mL | 26.15 mL | 52.3 mL |
| 1 mM | 2.62 mL | 13.08 mL | 26.15 mL |
| 5 mM | 0.52 mL | 2.62 mL | 5.23 mL |
*The above data is based on the productmolecular weight 382.39. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10538 |
|---|---|
| M. Wt | 382.39 |
| Formula | C22H23ClN2O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 79794-75-5 |
| Synonyms | Alavert, Claritin |
| SMILES | CCOC(=O)N1CCC(=C2C3=C(CCC4=C2N=CC=C4)C=C(C=C3)Cl)CC1 |
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