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Losmapimod (GW856553X)

目录号: A12526

p38 MAPK 抑制剂

Losmapimod (GW856553X)

Losmapimod (GW856553X) Chemical Structure

CAS NO. 585543-15-3

Losmapimod，也称为GW856553或GW856553X，是葛兰素史克（GlaxoSmithKline）开发的药物，可作为酶家族的选择性抑制剂，称为p38促分裂原活化蛋白激酶，其作用于p38α和p38β的pKi分别为8.1和7.6 。

库存： 现货

规格 价格 数量
10 mg
￥ 490.00
25 mg
￥ 980.00
50 mg
￥ 1,400.00
10mM * 1mL in DMSO
￥ 602.00
或
Warning 产品仅用于科学研究，不针对患者销售，望谅解.
产品详情

生物活性

Losmapimod，也称为GW856553或GW856553X，是葛兰素史克（GlaxoSmithKline）开发的药物，可作为酶家族的选择性抑制剂，称为p38促分裂原活化蛋白激酶，其作用于p38α和p38β的pKi分别为8.1和7.6 。
靶点信息
p38α p38β
8.1(pKi)7.6(pKi)

溶解度 *

In vitro DMSO 72 mg/mL (187.76 mM)
Water Insoluble
Ethanol Warmed: 39 mg/mL
* <1 mg/ml means slightly soluble or insoluble.
* Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
0.1 mM 26.08 mL 130.39 mL 260.78 mL
0.5 mM 5.22 mL 26.08 mL 52.16 mL
1 mM 2.61 mL 13.04 mL 26.08 mL
5 mM 0.52 mL 2.61 mL 5.22 mL

*The above data is based on the productmolecular weight 383.46. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号 A12526
作用机制 Inhibitor (抑制剂)
M. Wt 383.46
Formula C22H26FN3O2
Purity >99%
Storage

Store lyophilized at -20ºC, keep desiccated.
In lyophilized form, the chemical is stable for 36 months.
In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No. 585543-15-3
Synonyms GW856553, GW-856553, GW 856553, GW856553X
SMILES CC1=C(C=C(C=C1C2=NC=C(C=C2)C(=O)NCC(C)(C)C)C(=O)NC3CC3)F

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United StatesUnited States

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Email: sales@adooq.com

ChinaChina

Adooq 中国 (南京百鑫德诺生物科技有限公司)

免费电话: 400-025-6535

企业QQ: 400-025-6535

www.adooq.cn

sales@adooq.cn

United StatesUnited States

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