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LOXO-101 (ARRY-470, Larotrectinib)

LOXO-101 (ARRY-470, Larotrectinib)

Name: LOXO-101 (ARRY-470, Larotrectinib)
SKU: A15974

目录号: A15974

TRK 抑制剂

LOXO-101 (ARRY-470, Larotrectinib) Chemical Structure

CAS NO. 1223403-58-4

LOXO-101 (ARRY-470,Larotrectinib)是TRKA，TRKB和TRKC的口服生物有效，有效，ATP竞争性抑制剂。

库存：现货

规格	价格	数量
5 mg	￥ 525.00
10 mg	￥ 980.00
50 mg	￥ 2,940.00

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产品仅用于科学研究，不针对患者销售，望谅解.

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生物活性

LOXO-101 (ARRY-470,Larotrectinib)是TRKA，TRKB和TRKC的口服生物有效，有效，ATP竞争性抑制剂。

溶解度 *

In vitro	DMSO	85 mg/mL (198.39 mM)
	Water	Insoluble
	Ethanol	85 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	23.34 mL	116.7 mL	233.4 mL
0.5 mM	4.67 mL	23.34 mL	46.68 mL
1 mM	2.33 mL	11.67 mL	23.34 mL
5 mM	0.47 mL	2.33 mL	4.67 mL

*The above data is based on the productmolecular weight 428.44. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A15974
作用机制	Inhibitor (抑制剂)
M. Wt	428.44
Formula	C21H22F2N6O2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1223403-58-4
Synonyms	LOXO 101, LOXO101, ARRY470, ARRY 470
SMILES	O=C(N1CC[C@@H](C1)O)NC2=C3N=C(N4CCC[C@@H]4C5=CC(F)=CC=C5F)C=CN3N=C2