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LXH254是II型ATP竞争性抑制剂，可在皮摩尔浓度下抑制B/C RAF激酶活性，对456种人类激酶和基于细胞的测定具有高度选择性。
| In vitro | DMSO | 85 mg/mL (169.15 mM) | |
| Water | Insoluble | ||
| Ethanol | 29 mg/mL | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.9 mL | 99.5 mL | 199.01 mL |
| 0.5 mM | 3.98 mL | 19.9 mL | 39.8 mL |
| 1 mM | 1.99 mL | 9.95 mL | 19.9 mL |
| 5 mM | 0.4 mL | 1.99 mL | 3.98 mL |
*The above data is based on the productmolecular weight 502.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16841 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 502.49 |
| Formula | C25H25F3N4O4 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1800398-38-2 |
| Synonyms | LXH 254, LXH-254 |
| SMILES | O=C(C1=CC(C(F)(F)F)=NC=C1)NC2=CC=C(C)C(C3=CC(OCCO)=NC(N4CCOCC4)=C3)=C2 |
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