LXH254
目录号: A16841
pan-RAF 抑制剂
LXH254 是一种 II型ATP竞争性抑制剂，它能在皮克摩尔浓度下抑制B-和CRAF激酶活性，并且对456种人类激酶和细胞内实验中表现出高度的选择性。
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生物活性
| Discription | LXH254 is a type II ATP-competitive inhibitor that inhibits both B- and CRAF kinase activities at picomolar concentrations with a high degree of selectivity against a panel of 456 human kinases and in cell-based assays. | |||||
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产品信息
| 目录号 | A16841 |
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| 分子式 | C25H25F3N4O4 |
| 分子量 | 502.49 |
| CAS号 | 1800398-38-2 |
| SMILES | O=C(C1=CC(C(F)(F)F)=NC=C1)NC2=CC=C(C)C(C3=CC(OCCO)=NC(N4CCOCC4)=C3)=C2 |
| 其他名称 | LXH 254, LXH-254 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 85 mg/mL (169.15 mM) | |
| Water | Insoluble | ||
| Ethanol | 29 mg/mL | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.9 mL | 99.5 mL | 199.01 mL |
| 0.5 mM | 3.98 mL | 19.9 mL | 39.8 mL |
| 1 mM | 1.99 mL | 9.95 mL | 19.9 mL |
| 5 mM | 0.4 mL | 1.99 mL | 3.98 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 1800398-38-2 | 1800398-38-2 供应商 | 1800398-38-2 花费 | 1800398-38-2 生产商 | 订购 1800398-38-2 | 1800398-38-2 代理商