LXS196
目录号: A19419
PKC 抑制剂
LXS196 是一种强效、选择性且可口服的蛋白激酶C（PKC）抑制剂，其半抑制浓度（IC50）值分别为 PKCα 1.9 nM、PKCθ 0.4 nM 和 GSK3β 3.1 μM。它可用于治疗葡萄膜黑色素瘤。
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生物活性
| Discription | LXS196 is a potent, selective and orally active protein kinase C (PKC) inhibitor, with IC50 values of 1.9 nM, 0.4 nM and 3.1 μM for PKCα, PKCθ and GSK3β, respectively. It can be used for the treatment of uveal melanoma. | ||
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产品信息
| 目录号 | A19419 |
|---|---|
| 分子式 | C22H23F3N8O |
| 分子量 | 472.47 |
| CAS号 | 1874276-76-2 |
| SMILES | NC1=C(C(NC2=C(N3CCC(C)(N)CC3)C=CC=N2)=O)N=C(C4=NC=CC=C4C(F)(F)F)C=N1 |
| 其他名称 | LXS 196, LXS-196 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 20 mg/mL (42.33 mM) | |
| Water | Insoluble | ||
| Ethanol | 5 mg/mL (10.58 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.17 mL | 105.83 mL | 211.65 mL |
| 0.5 mM | 4.23 mL | 21.17 mL | 42.33 mL |
| 1 mM | 2.12 mL | 10.58 mL | 21.17 mL |
| 5 mM | 0.42 mL | 2.12 mL | 4.23 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 1874276-76-2 | 1874276-76-2 供应商 | 1874276-76-2 花费 | 1874276-76-2 生产商 | 订购 1874276-76-2 | 1874276-76-2 代理商