LY3023414

Name: LY3023414
SKU: A16126

目录号: A16126

PI3K/mTOR Dual 抑制剂

Product Citations (1)

LY3023414 Chemical Structure

CAS NO. 1386874-06-1

LY3023414是从专利WO/2012097039A1（化合物实施例1）中提取的I类PI3K同种型，mTOR和DNA-PK的口服ATP竞争性抑制剂，对Akt1（pT308）的IC50为64.9 nM，42.1 nM，10.6 nM和19.1 nM。），Akt1（pS473），P70S6（pT389），S6RP（pS240/242）。

库存：现货

规格	价格	数量
5 mg	￥ 525.00
10 mg	￥ 910.00
50 mg	￥ 3,465.00

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生物活性

靶点信息

class I PI3K isoforms	mTOR kinase	DNA-PK

溶解度 *

In vitro	DMSO	44 mg/mL (108.24 mM)
	Water	Insoluble
	Ethanol	57 mg/mL (140.22 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	24.6 mL	123 mL	246.01 mL
0.5 mM	4.92 mL	24.6 mL	49.2 mL
1 mM	2.46 mL	12.3 mL	24.6 mL
5 mM	0.49 mL	2.46 mL	4.92 mL

*The above data is based on the productmolecular weight 406.49. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A16126
作用机制	Inhibitor (抑制剂)
M. Wt	406.49
Formula	C23H26N4O3
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1386874-06-1
Synonyms	LY-3023414, LY 3023414
SMILES	CC(CN1C2=C3C=C(C=CC3=NC=C2N(C1=O)C)C4=CC(=CN=C4)C(C)(C)O)OC