LY3023414
LY3023414 是一种口服 ATP 竞争性抑制剂，针对 class I PI3K isoforms、mTOR 和 DNA-PK，源自专利 WO/2012097039A1，化合物示例 1，对 Akt1(pT308)、Akt1 (pS473)、P70S6(pT389)、S6RP(pS240/242) 的 IC50 分别为 64.9 nM、42.1 nM、10.6 nM、19.1 nM。
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生物活性
| Discription | LY3023414 is an oral ATP competitive inhibitor of the class I PI3K isoforms, mTOR and DNA-PK, extracted from patent WO/2012097039A1, compound example 1, has an IC50 of 64.9 nM, 42.1 nM, 10.6 nM, 19.1 nM for Akt1(pT308), Akt1 (pS473), P70S6(pT389), S6RP(pS240/242). | ||
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产品信息
| 目录号 | A16126 |
|---|---|
| 分子式 | C23H26N4O3 |
| 分子量 | 406.49 |
| CAS号 | 1386874-06-1 |
| SMILES | CC(CN1C2=C3C=C(C=CC3=NC=C2N(C1=O)C)C4=CC(=CN=C4)C(C)(C)O)OC |
| 其他名称 | LY-3023414, LY 3023414 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 44 mg/mL (108.24 mM) | |
| Water | Insoluble | ||
| Ethanol | 57 mg/mL (140.22 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.6 mL | 123 mL | 246.01 mL |
| 0.5 mM | 4.92 mL | 24.6 mL | 49.2 mL |
| 1 mM | 2.46 mL | 12.3 mL | 24.6 mL |
| 5 mM | 0.49 mL | 2.46 mL | 4.92 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 1386874-06-1 | 1386874-06-1 供应商 | 1386874-06-1 花费 | 1386874-06-1 生产商 | 订购 1386874-06-1 | 1386874-06-1 代理商