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LY3214996是一种选择性的新型ERK1/2抑制剂，在生化分析中两种酶的IC50为5 nM。它有效抑制BRAF和RAS突变癌细胞系中的细胞磷酸RSK1。
| In vitro | DMSO | 24 mg/mL (52.91 mM) | |
| Water | Insoluble | ||
| Ethanol | 14 mg/mL (30.86 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.05 mL | 110.24 mL | 220.48 mL |
| 0.5 mM | 4.41 mL | 22.05 mL | 44.1 mL |
| 1 mM | 2.2 mL | 11.02 mL | 22.05 mL |
| 5 mM | 0.44 mL | 2.2 mL | 4.41 mL |
*The above data is based on the productmolecular weight 453.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16843 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 453.56 |
| Formula | C22H27N7O2S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1951483-29-6 |
| Synonyms | LY 3214996, LY-3214996 |
| SMILES | CC(N(CCN1CCOCC1)C2=O)(C)C3=C2C=C(S3)C4=CC=NC(NC5=CC=NN5C)=N4 |
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