LY3214996
目录号: A16843
ERK 抑制剂
LY3214996 是一种选择性且新颖的 ERK1/2 抑制剂，在生化实验中对两种酶的 IC50 值均为 5 nM。它在 BRAF 和 RAS 突变癌细胞系中强效抑制细胞内磷酸化 RSK1。
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生物活性
| Discription | LY3214996 is a selective and novel ERK1/2 inhibitor with IC50 of 5 nM for both enzymes in biochemical assays. It potently inhibits cellular phospho-RSK1 in BRAF and RAS mutant cancer cell lines. | ||
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产品信息
| 目录号 | A16843 |
|---|---|
| 分子式 | C22H27N7O2S |
| 分子量 | 453.56 |
| CAS号 | 1951483-29-6 |
| SMILES | CC(N(CCN1CCOCC1)C2=O)(C)C3=C2C=C(S3)C4=CC=NC(NC5=CC=NN5C)=N4 |
| 其他名称 | LY 3214996, LY-3214996 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 24 mg/mL (52.91 mM) | |
| Water | Insoluble | ||
| Ethanol | 14 mg/mL (30.86 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.05 mL | 110.24 mL | 220.48 mL |
| 0.5 mM | 4.41 mL | 22.05 mL | 44.1 mL |
| 1 mM | 2.2 mL | 11.02 mL | 22.05 mL |
| 5 mM | 0.44 mL | 2.2 mL | 4.41 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 1951483-29-6 | 1951483-29-6 供应商 | 1951483-29-6 花费 | 1951483-29-6 生产商 | 订购 1951483-29-6 | 1951483-29-6 代理商