产品详情

生物活性

LY364947是一种二杂芳基取代的吡唑类化合物，用作TGF-βRI（TGF-β受体I激酶）的选择性ATP竞争性抑制剂。

靶点信息

TGFβRI (Cell-free assay)	RIPK2 (Cell-free assay)	CK1δ (Cell-free assay)	TGFβRII (Cell-free assay)	MLK-7K (Cell-free assay)
59 nM	0.11 μM	0.22 μM	0.4 μM	1.4 μM

溶解度 *

In vitro (25°C)	DMSO	1 mg/mL (3.67 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	4% DMSO+30% PEG 300+ddH2O	0.71 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	36.72 mL	183.62 mL	367.24 mL
0.5 mM	7.34 mL	36.72 mL	73.45 mL
1 mM	3.67 mL	18.36 mL	36.72 mL
5 mM	0.73 mL	3.67 mL	7.34 mL

*The above data is based on the productmolecular weight 272.3. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A13446
作用机制	Inhibitor (抑制剂)
M. Wt	272.3
Formula	C17H12N4
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	396129-53-6
Synonyms	HTS 466284 ,TGF-β RI Kinase Inhibitor
SMILES	C1=CC=C2C(=C1)C(=CC=N2)C3=C(NN=C3)C4=CC=CC=N4