Macitentan

Name: Macitentan
SKU: A11492

目录号: A11492

Endothelin receptor 拮抗剂

Macitentan Chemical Structure

CAS NO. 441798-33-0

Macitentan是一种口服活性非肽双重ETA/ETB(内皮素) receptor双重拮抗剂，IC50为0.5 nM/391 nM。用于治疗特发性肺纤维化(IPF)和肺动脉高压(PAH)。

库存：现货

规格	价格	数量
5 mg	￥ 315.00
10 mg	￥ 455.00

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生物活性

Macitentan是一种口服活性非肽双重ETA/ETB(内皮素) receptor双重拮抗剂，IC50为0.5 nM/391 nM。用于治疗特发性肺纤维化(IPF)和肺动脉高压(PAH)。

靶点信息

ET-A	ET-B
0.5 nM	391 nM

溶解度 *

In vitro	DMSO	87 mg/mL (147.88 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	17 mL	84.99 mL	169.99 mL
0.5 mM	3.4 mL	17 mL	34 mL
1 mM	1.7 mL	8.5 mL	17 mL
5 mM	0.34 mL	1.7 mL	3.4 mL

*The above data is based on the productmolecular weight 588.27. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11492
作用机制	Antagonist (拮抗剂)
M. Wt	588.27
Formula	C19H20Br2N6O4S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	441798-33-0
Synonyms	ACT 064992, ACT-064992, ACT064992
SMILES	CCCNS(=O)(=O)NC1=C(C(=NC=N1)OCCOC2=NC=C(C=N2)Br)C3=CC=C(C=C3)Br