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Masitinib mesylate是Kit和PDGFRα/β的新型抑制剂，IC50为200 nM和540 nM/800 nM，对ABL和c-Fms的抑制作用较弱。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 16.81 mL | 84.07 mL | 168.14 mL |
| 0.5 mM | 3.36 mL | 16.81 mL | 33.63 mL |
| 1 mM | 1.68 mL | 8.41 mL | 16.81 mL |
| 5 mM | 0.34 mL | 1.68 mL | 3.36 mL |
*The above data is based on the productmolecular weight 594.75. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A15152 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 594.75 |
| Formula | C29H34N6O4S2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1048007-93-7 |
| Synonyms | AB1010 mesylate, Masivet mesylate, AB-1010 mesylate, AB 1010 mesylate |
| SMILES | CC1=C(C=C(C=C1)NC(=O)C2=CC=C(C=C2)CN3CCN(CC3)C)NC4=NC(=CS4)C5=CN=CC=C5.CS(=O)(=O)O |
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