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MC1568是HDAC抑制剂的成员，它通过修饰细胞周期的各种重要基因的基因表达（主要在G1期）来抑制II类组蛋白脱乙酰基酶，从而导致细胞凋亡导致乳腺癌细胞死亡。
靶点信息
| HD1-A (Maize) (Cell-free assay) | HD1-B (Maize) (Cell-free assay) | |||
| 100 nM | 3.4 μM |
| In vitro (25°C) | DMSO | 12 mg/mL (38.18 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 0.5% CMC | 4 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 31.82 mL | 159.08 mL | 318.17 mL |
| 0.5 mM | 6.36 mL | 31.82 mL | 63.63 mL |
| 1 mM | 3.18 mL | 15.91 mL | 31.82 mL |
| 5 mM | 0.64 mL | 3.18 mL | 6.36 mL |
*The above data is based on the productmolecular weight 314.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10560 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 314.3 |
| Formula | C17H15FN2O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 852475-26-4 |
| Synonyms | MC-1568 |
| SMILES | CN1C=C(C=C1/C=C/C(=O)NO)/C=C/C(=O)C2=CC(=CC=C2)F |
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