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MCC950 (CP-456773, CRID3) is a potent and selective inhibitor of NLRP3 (NOD-like receptor (NLR) family, pyrin domain-containing protein 3) with IC50 of 7.5 nM and 8.1 nM in BMDMs and HMDMs, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.72 mL | 123.62 mL | 247.23 mL |
| 0.5 mM | 4.94 mL | 24.72 mL | 49.45 mL |
| 1 mM | 2.47 mL | 12.36 mL | 24.72 mL |
| 5 mM | 0.49 mL | 2.47 mL | 4.94 mL |
*The above data is based on the productmolecular weight 404.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A22097 |
|---|---|
| M. Wt | 404.48 |
| Formula | C20H24N2O5S |
| Solubility | DMSO |
| Purity | >98% |
| Storage | at -20°C 2 years |
| CAS No. | 210826-40-7 |
| SMILES | O=S(NC(NC1=C(CCC2)C2=CC3=C1CCC3)=O)(C4=CC(C(C)(O)C)=CO4)=O |
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