MD-224

Name: MD-224
SKU: A18712
Price: 385 CNY
Rating: 5 (1 reviews)

目录号: A18712

MDM2 degrader

1 篇发表文献

MD-224 是一种基于蛋白质降解靶向嵌合体（PROTAC）概念的首创类和高效的小分子人类鼠双分钟2（MDM2）降解剂。MD-224 有潜力成为一种新类别的抗癌药物。

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Grouped product items
规格	价格	库存
1mg	¥385.00	现货
5mg	¥1,050.00	现货
10mg	¥1,960.00	现货
25mg	¥3,395.00	现货
50mg	¥4,760.00	现货
100mg	¥6,825.00	现货
200mg	¥9,415.00	现货
*10mM 1mL in DMSO**	¥1,120.00	现货
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Data Sheet

SDS

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Adooq用户使用MD-224发表的1篇文献

Lingling Chen, .et al. , Biochem Pharmacol, 2024, Nov 29:232:116688 PMID: 39617210

生物活性

Discription

MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 has the potential to be a new class of anticancer agent.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A18712
分子式	C48H43Cl2FN6O6
分子量	889.8
CAS号	2136247-12-4
SMILES	FC1=C(Cl)C=CC=C1[C@@H]2[C@@]3(C(C=CC(Cl)=C4)=C4NC3=O)C5(CCCCC5)N[C@H]2C(NC6=CC=C(C(NCCCC#CC7=C(CN(C8C(NC(CC8)=O)=O)C9=O)C9=CC=C7)=O)C=C6)=O
其他名称	MD224, MD 224
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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