MDM2

Inhibitory Selectivity

Catalog No.	Inhibitor Name	Mdm2	Other
A10657	Nutlin-3	**
A11501	Nutlin-3a	***
A11502	Nutlin-3b	*
A16348	MX69	**
A15440	MI-773 (SAR405838)	****	p53
A14211	Idasanutlin (RG-7388)	****
A11523	RG-7112	***
A14118	YH239-EE

Notes:
1.Hover mouse over " * " to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of " * " is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.

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RO8994

Catalog No. A20865
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MDM2 inhibitor

RO8994 is a highly potent and selective series of spiroindolinone small-molecule MDM2 inhibitor, with IC50 of 5 nM (HTRF binding assays) and 20 nM (MTT proliferation assays). 了解更多

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APG-115

Catalog No. A12575
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MDM2 inhibitor

APG-115 (AA-115) is an orally active MDM2 protein inhibitor binding to MDM2 protein with IC50 and Ki values of 3.8 nM and 1 nM, respectively. 了解更多

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MA242

Catalog No. A13480
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dual MDM2/NFAT1 inhibitor

MA242 is a dual inhibitor of murine double minute 2 (MDM2) and nuclear factor of activated T cells 1 (NFAT1) for Pancreatic Cancer Therapy. 了解更多

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PROTAC MDM2 Degrader-4

Catalog No. A18877
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MDM2 inhibitor

PROTAC MDM2 Degrader-4 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-4 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase. 了解更多

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PROTAC MDM2 Degrader-3

Catalog No. A18883
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MDM2 degrader

PROTAC MDM2 Degrader-3 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-3 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase. 了解更多

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PROTAC MDM2 Degrader-2

Catalog No. A18890
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MDM2 inhibitor

PROTAC MDM2 Degrader-2 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-2 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase. 了解更多

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PROTAC MDM2 Degrader-1

Catalog No. A18897
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MDM2 degrader

PROTAC MDM2 Degrader-1 is a MDM2 degrader based on PROTAC technology. PROTAC MDM2 Degrader-1 composes of a potent MDM2 inhibitor, linker, and the MDM2 ligand for E3 ubiquitin ligase. 了解更多

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Nutlin carboxylic acid

Catalog No. A18917
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Nutlin 3-based MDM2 ligand

Nutlin carboxylic acid (MDM2 ligand 1) is the Nutlin 3-based MDM2 ligand. Nutlin carboxylic acid (MDM2 ligand 1) can be connected to the ligand for protein by a linker to form PROTACs. 了解更多

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(4R,5S)-nutlin carboxylic acid

Catalog No. A18924
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Nutlin 3-based MDM2 ligand

(4R,5S)-nutlin carboxylic acid (MDM2 ligand 2) is the Nutlin 3-based MDM2 ligand. (4R,5S)-nutlin carboxylic acid can be connected to the ligand for protein by a linker to form PROTACs. 了解更多

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MI-773

Catalog No. A15440
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MDM2 抑制剂

MI-773是可用的MDM2拮抗剂，Ki为0.88 nM。了解更多

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WR 1065

Catalog No. A15353
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P53/p21waf-1/MDM2 activator

WR 1065是一种氨磷汀（Ethyol）的去磷酸化代谢产物，可防止受到辐射的直接和延迟影响。了解更多

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SJ 172550

Catalog No. A15352
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MDMX 抑制剂

SJ 172550是第一种MD50抑制剂，EC50为0.84 uM；与MDMX可逆结合，并有效杀死其中放大了MDMX表达的成视网膜细胞瘤细胞。了解更多

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NSC-207895 (XI-006)

Catalog No. A11179
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MDMX 抑制剂

NSC-207895 (XI-006)是细胞可渗透的苯并呋喃化合物，可通过抑制MDMX启动子转录活性（IC50 = 2.5 ?M，下调MCF-7，LNCaP和A549细胞中的p53负调节剂MDMX蛋白水平（1至10 ?M，持续16至24 h）），导致增强的p53稳定和激活。了解更多

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Nutlin-3

Catalog No. A10657
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Mdm2 拮抗剂

Nutlin-3是一种有效的，选择性Mdm2(它自身和p53的环指依赖性泛素蛋白连接酶)拮抗剂，是有效的凋亡诱导剂。了解更多

Product Citations (4)

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- Maxime Parisotto, .et al. PTEN deletion in luminal cells of mature prostate induces replication stress and senescence in vivo, J Exp Med, 2018, Jun 4; 215(6): 1749-1763 PMID: 29743291
- Ohmuro-Matsuyama Y, .et al. Evaluation of protein-ligand interactions using the luminescent interaction assay FlimPIA with streptavidin-biotin linkage, Anal Biochem, 2018, Dec 15;563:61-66 PMID: 30316750
- Alisa A. Garaeva, .et al. Mitochondrial dysfunction induces SESN2 gene expression through Activating Transcription Factor 4, Cell Cycle, 2016, 15(1): 64-71 PMID: 26771712
- A G Evstafieva, .et al. A sustained deficiency of mitochondrial respiratory complex III induces an apoptotic cell death through the p53-mediated inhibition of pro-survival activities of the activating transcription factor 4, Cell Death Dis., 2014, 5(11): e1511. PMID: 25375376
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Nutlin 3a

Catalog No. A11501
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MDM2 抑制剂

Nutlin 3a是与p53结合的MDM2(小鼠双分钟2)有效抑制剂，可诱导p53调控基因的表达，并在表达功能性p53的细胞中表现出有效的抗增殖活性。了解更多

Product Citations (3)

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- Sho Watanabe, .et al. Schlafen 11 is a novel target for mucosal regeneration in Ulcerative Colitis, J Crohns Colitis, 2021, Feb 17 PMID: 33596306
- Shun Zhang, .et al. Sensitization of Gastric Cancer Cells to Irinotecan by p53 Activation, BPB Reports, 2019, 2, 130-133
- Momoko Ishimine, .et al. The Relationship between TP53 Gene Status and Carboxylesterase 2 Expression in Human Colorectal Cancer, Dis Markers, 2018, 2018: 5280736 PMID: 29651325
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Nutlin 3b

Catalog No. A11502
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MDM2 抑制剂

Nutlin 3b是p53/MDM2拮抗剂或抑制剂，IC50值为13.6 uM，与相反的（-）-对映体Nutlin-3a相比，Nutlin-3的有效（+）-对映体少150倍。了解更多

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Idasanutlin (RG7388)

Catalog No. A14211
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MDM2/p53 抑制剂

Idasanutlin (RG7388)是一种有效的选择性p53-MDM2抑制剂。了解更多

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YH239-EE

Catalog No. A14118
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Mdm2 抑制剂

YH239-EE是有效的p53-MDM2拮抗剂和凋亡诱导剂。了解更多

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AMG232

Catalog No. A14394
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MDM2 抑制剂

AMG 232是MDM2-p53相互作用的高效，选择性生物利用的哌啶酮抑制剂（SPR KD = 0.045 nM，SJSA-1 EdU IC50 = 9.1 nM）。了解更多

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p53 and MDM2 proteins-interaction-inhibitor chiral

Catalog No. A15201
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p53-MDM2 interaction 抑制剂

p53和MDM2蛋白相互作用抑制剂手性是p53和MDM2蛋白之间相互作用的抑制剂。了解更多

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p53 and MDM2 proteins-interaction-inhibitor racemic

Catalog No. A15202
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p53-MDM2 interaction 抑制剂

p53和MDM2蛋白相互作用抑制剂消旋体是p53和MDM2蛋白之间相互作用的抑制剂。了解更多

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HDM201

Catalog No. A16834
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MDM2 抑制剂

HDM201是新型，高效且选择性的p53-Mdm2相互作用抑制剂，其对Mdm2的亲和常数在皮摩尔范围内，相对Mdm4的选择性比大于10000倍。了解更多

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RO-5963

Catalog No. A18813
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MDM2/MDMX inhibitor

RO-5963 is an inhibitor of the interaction of both MDM2 and MDMX with p53 with IC50s of ~17 nM and ~24 nM, respectively. 了解更多

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- 最新产品
MD-224

Catalog No. A18712
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MDM2 degrader

MD-224 is a first-in-class and highly potent small-molecule human murine double minute 2 (MDM2) degrader based on the proteolysistargeting chimera (PROTAC) concept. MD-224 has the potential to be a new class of anticancer agent. 了解更多

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MI-1061

Catalog No. A18450
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MDM2 inhibitor

MI-1061 is a potent, orally bioavailable, and chemically stable MDM2 (MDM2-p53 interaction) inhibitor (IC50=4.4 nM; Ki=0.16 nM). MI-1061 potently activates p53, induces apoptosis, and has anti-tumor activity. 了解更多

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MX-69

Catalog No. A16348
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MDM2/XIAP 抑制剂

MX-69是MDM2/XIAP抑制剂，用于癌症治疗。了解更多

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NVP-CGM097

Catalog No. A16326
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MDM2 抑制剂

NVP-CGM097是一种有效的选择性MDM2抑制剂。具有潜在抗肿瘤活性的口服生物利用型HDM2拮抗剂。了解更多

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MI-773 (SAR405838)

Catalog No. A14423
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Mdm2 抑制剂

MI-773 (SAR405838)是一种新的MDM2-p53相互作用的小分子抑制剂，以高亲和力（Ki = 0.88 nM）结合MDM2，并阻断p53-MDM2相互作用。了解更多

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WK23

Catalog No. A14051
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MDM2/MDMX 抑制剂

WK23是基于四个芳香族基团的抑制剂，能够有效填充MDM2/MDMX的结合口袋，其对MDM2/MDMX的中位抑制浓度（IC50）值分别为1.17和36 uM。了解更多

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RG7112

Catalog No. A11523
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selective p53-MDM2 抑制剂

RG7112是首个临床小分子MDM2抑制剂，HTRF IC50为18 nM，设计用于占据MDM2的p53结合口袋。了解更多

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Kevetrin HCl

Catalog No. A13797
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Kevetrin (thioureidobutyronitrile)是一种水溶性小分子，是肿瘤抑制蛋白p53的激活剂，具有潜在的抗肿瘤活性。了解更多

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MDM2 Inhibitor

Catalog No. A13582
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MDM2 抑制剂

MDM2 Inhibitor是一种细胞可渗透的硼烷基查尔酮，表现出与MDM2的强结合，并不可逆地破坏MDM2/p53蛋白复合物。了解更多

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