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MGCD-265 (Glesatinib)是一种多靶酪氨酸激酶抑制剂，可与多种RTK（包括c-Met受体（HGFR）结合并抑制其磷酸化。Tek/Tie-2受体；VEGFR类型1、2和3；和MST1R。
Targets
| Target | Value |
|---|---|
| Met | IC50: 1nM |
| RON | IC50: 2nM |
| VEGFR1 | IC50: 3nM |
| VEGFR2 | IC50: 3nM |
| VEGFR3 | IC50: 4nM |
| Tie-2 | IC50: 7nM |
| In vitro | DMSO | 99 mg/mL (191.26 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 19.32 mL | 96.6 mL | 193.2 mL |
| 0.5 mM | 3.86 mL | 19.32 mL | 38.64 mL |
| 1 mM | 1.93 mL | 9.66 mL | 19.32 mL |
| 5 mM | 0.39 mL | 1.93 mL | 3.86 mL |
*The above data is based on the productmolecular weight 517.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A10587 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 517.6 |
| Formula | C26H20FN5O2S2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 875337-44-3 |
| Synonyms | MGCD265 |
| SMILES | CN1C=C(N=C1)C2=CC3=NC=CC(=C3S2)OC4=C(C=C(C=C4)NC(=S)NC(=O)CC5=CC=CC=C5)F |
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