MGCD-265 (Glesatinib)

Name: MGCD-265 (Glesatinib)
SKU: A10587

目录号: A10587

c-Met 抑制剂

MGCD-265 (Glesatinib) Chemical Structure

CAS NO. 875337-44-3

MGCD-265 (Glesatinib)是一种多靶酪氨酸激酶抑制剂，可与多种RTK（包括c-Met受体（HGFR）结合并抑制其磷酸化。Tek/Tie-2受体；VEGFR类型1、2和3；和MST1R。

库存：现货

规格	价格	数量
5 mg	￥ 840.00
10 mg	￥ 1,540.00
50 mg	￥ 4,550.00
100 mg	￥ 6,860.00
10mM * 1mL in DMSO	￥ 1,498.00

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生物活性

MGCD-265 (Glesatinib)是一种多靶酪氨酸激酶抑制剂，可与多种RTK（包括c-Met受体（HGFR）结合并抑制其磷酸化。Tek/Tie-2受体；VEGFR类型1、2和3；和MST1R。

Targets

Target	Value
Met	IC50: 1nM
RON	IC50: 2nM
VEGFR1	IC50: 3nM
VEGFR2	IC50: 3nM
VEGFR3	IC50: 4nM
Tie-2	IC50: 7nM

溶解度 *

In vitro	DMSO	99 mg/mL (191.26 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.32 mL	96.6 mL	193.2 mL
0.5 mM	3.86 mL	19.32 mL	38.64 mL
1 mM	1.93 mL	9.66 mL	19.32 mL
5 mM	0.39 mL	1.93 mL	3.86 mL

*The above data is based on the productmolecular weight 517.6 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10587
作用机制	Inhibitor (抑制剂)
M. Wt	517.6
Formula	C26H20FN5O2S2
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	875337-44-3
Synonyms	MGCD265
SMILES	CN1C=C(N=C1)C2=CC3=NC=CC(=C3S2)OC4=C(C=C(C=C4)NC(=S)NC(=O)CC5=CC=CC=C5)F