MK-0674
目录号: A21558
cathepsin K inhibitor
MK-0674 是一种强效、口服生物利用度高且选择性的 cathepsin K 抑制剂,其 IC50 为 0.4 nM,相较于 Cat B、Cat F、Cat L 和 Cat S,显示出 1156、1465、11857 和 243 倍的选择性。
Discription | MK-0674 is a potent, orally bioavailable and selective cathepsin K inhibitor, with an IC50 of 0.4 nM, shows 1156, 1465, 11857 and 243 fold selectivity over Cat B, Cat F, Cat L and Cat S. |
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目录号 | A21558 |
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分子式 | C26H27F6N3O2 |
分子量 | 527.5 |
CAS号 | 887781-62-6 |
SMILES | N#CC1(CC1)NC([C@H](CC(C)(C)F)N[C@@H](C2=CC=C(C3=CC=C(C=C3)[C@@H](O)C(F)F)C=C2)C(F)(F)F)=O |
其他名称 | MK0674, MK 0674 |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2