MK-0812

Name: MK-0812
SKU: A11127
Price: 1225 CNY
Rating: 5 (1 reviews)

目录号: A11127

CCR2 拮抗剂

1 篇发表文献

MK-0812 是一种强效且选择性的 CCR2 拮抗剂，对人类单核细胞上的 CCR2 具有低纳摩尔级的亲和力，并在趋化性测定中也显示出低纳摩尔级的效果。它在临床前物种中具有良好的药代动力学（PK）特性，并在动物模型中显示出了疗效。

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Grouped product items
规格	价格	库存
1mg	¥1,225.00	现货
5mg	¥1,260.00	现货
10mg	¥2,415.00	现货
50mg	¥10,465.00	现货
100mg	¥17,465.00	现货
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Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用MK-0812发表的1篇文献

Murakami K, .et al. , Vet Immunol Immunopathol, 2016, Dec;182:52-58 PMID: 27863550

生物活性

Discription

MK-0812 is a potent and selective CCR2 antagonist with low nM affinity for CCR2 on human monocytes and low nM in the chemotaxis assay. It has good PK profiles in preclinical species and demonstrated efficacy in animal models.

Targets

Target	Value

产品信息

目录号	A11127
分子式	C24H34F3N3O3
分子量	469.5
CAS号	624733-88-6
SMILES	CC(C)[C@@]1(CC[C@H](C1)N[C@H]2CCOC[C@H]2OC)C(=O)N3CCC4=NC=C(C=C4C3)C(F)(F)F
其他名称	MK0812
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

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