MK-5108 (VX-689)

Name: MK-5108 (VX-689)
SKU: A11410

目录号: A11410

Aurora A Kinase 抑制剂

Product Citations (1)

MK-5108 (VX-689) Chemical Structure

CAS NO. 1010085-13-8

MK-5108，也称为VX-689，是Aurora A激酶ATP结合位点的竞争性抑制剂。

库存：现货

规格	价格	数量
5 mg	￥ 700.00
10 mg	￥ 1,190.00
50 mg	￥ 3,150.00
100 mg	￥ 5,250.00
10mM * 1mL in DMSO	￥ 840.00

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生物活性

MK-5108，也称为VX-689，是Aurora A激酶ATP结合位点的竞争性抑制剂。

靶点信息

Aurora A (Cell-free assay)
0.064 nM

溶解度 *

In vitro (25°C)	DMSO	81 mg/mL (175.35 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% methylcellulose+0.2% Tween 80	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	21.65 mL	108.25 mL	216.5 mL
0.5 mM	4.33 mL	21.65 mL	43.3 mL
1 mM	2.16 mL	10.82 mL	21.65 mL
5 mM	0.43 mL	2.16 mL	4.33 mL

*The above data is based on the productmolecular weight 461.9 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A11410
作用机制	Inhibitor (抑制剂)
M. Wt	461.9
Formula	C22H21ClFN3O3S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1010085-13-8
Synonyms	MK5108, VX689
SMILES	C1CC(CCC1OC2=C(C(=CC=C2)Cl)F)(CC3=NC(=CC=C3)NC4=NC=CS4)C(=O)O