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MK-6096 (Filorexant)是目前正处于失眠临床开发中的口服生物利用型有效且选择性可逆的OX（1）R和OX（2）R拮抗剂。MK-6096表现出对人OX（1）R和OX（2）R的有效结合和拮抗作用（结合时<3 nM，FLIPR中为11 nM），对超过170个受体和 酶。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.78 mL | 118.91 mL | 237.82 mL |
| 0.5 mM | 4.76 mL | 23.78 mL | 47.56 mL |
| 1 mM | 2.38 mL | 11.89 mL | 23.78 mL |
| 5 mM | 0.48 mL | 2.38 mL | 4.76 mL |
*The above data is based on the productmolecular weight 420.48. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13168 |
|---|---|
| 作用机制 | Antagonist (拮抗剂) |
| M. Wt | 420.48 |
| Formula | C24H25FN4O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1088991-73-4 |
| Synonyms | MK6096, MK-6096, MK 6096 |
| SMILES | CC1=CC=C(C2=NC=CC=N2)C(C(N3C[C@@H](COC4=NC=C(F)C=C4)CC[C@@H]3C)=O)=C1 |
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