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MK-8033是一种新的特异性ATP竞争性c-Met/Ron双重抑制剂 ，对野生型c-Met的IC50为1 nM，对c-Met N1100Y的IC50为2.0 nM。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 21.21 mL | 106.04 mL | 212.08 mL |
| 0.5 mM | 4.24 mL | 21.21 mL | 42.42 mL |
| 1 mM | 2.12 mL | 10.6 mL | 21.21 mL |
| 5 mM | 0.42 mL | 2.12 mL | 4.24 mL |
*The above data is based on the productmolecular weight 471.53. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11489 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 471.53 |
| Formula | C25H21N5O3S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1001917-37-8 |
| Synonyms | MK 8033, MK8033 |
| SMILES | CN1C=C(C=N1)C2=CN=C3C=CC4=C(C=C(C=C4)CS(=O)(=O)NCC5=CC=CC=N5)C(=O)C3=C2 |
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