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MK-8353 (SCH900353)是一种口服生物利用型，选择性和有效的ERK抑制剂，在体外抑制激活的ERK1和ERK2，IC50值分别为23.0 nM和8.8 nM（IMAP激酶测定），以及未激活的ERK2，具有IC50值 0.5 nM（MEK1-ERK2耦合测定）。
| In vitro | DMSO | 45 mg/mL (65.04 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 14.45 mL | 72.27 mL | 144.54 mL |
| 0.5 mM | 2.89 mL | 14.45 mL | 28.91 mL |
| 1 mM | 1.45 mL | 7.23 mL | 14.45 mL |
| 5 mM | 0.29 mL | 1.45 mL | 2.89 mL |
*The above data is based on the productmolecular weight 691.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A16838 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 691.84 |
| Formula | C37H41N9O3S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1184173-73-6 |
| Synonyms | MK8353, MK 8353, SCH 900353, SCH-900353 |
| SMILES | O=C(CN1CC[C@@](SC)(C(NC2=CC=C(NN=C3C4=CC=C(OC(C)C)N=C4)C3=C2)=O)C1)N5CCC(C6=CC=C(C7=NN(C)C=N7)C=C6)=CC5 |
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