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MK-8353 (SCH900353)

MK-8353 (SCH900353)

Name: MK-8353 (SCH900353)
SKU: A16838

目录号: A16838

ERK 抑制剂

MK-8353 (SCH900353) Chemical Structure

CAS NO. 1184173-73-6

MK-8353 (SCH900353)是一种口服生物利用型，选择性和有效的ERK抑制剂，在体外抑制激活的ERK1和ERK2，IC50值分别为23.0 nM和8.8 nM（IMAP激酶测定），以及未激活的ERK2，具有IC50值 0.5 nM（MEK1-ERK2耦合测定）。

库存：现货

规格	价格	数量
2 mg	￥ 840.00
5 mg	￥ 1,106.00
10 mg	￥ 1,883.00
50 mg	￥ 5,530.00

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产品详情

溶解度 *

In vitro	DMSO	45 mg/mL (65.04 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	14.45 mL	72.27 mL	144.54 mL
0.5 mM	2.89 mL	14.45 mL	28.91 mL
1 mM	1.45 mL	7.23 mL	14.45 mL
5 mM	0.29 mL	1.45 mL	2.89 mL

*The above data is based on the productmolecular weight 691.84. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A16838
作用机制	Inhibitor (抑制剂)
M. Wt	691.84
Formula	C37H41N9O3S
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1184173-73-6
Synonyms	MK8353, MK 8353, SCH 900353, SCH-900353
SMILES	O=C(CN1CC[C@@](SC)(C(NC2=CC=C(NN=C3C4=CC=C(OC(C)C)N=C4)C3=C2)=O)C1)N5CCC(C6=CC=C(C7=NN(C)C=N7)C=C6)=CC5