MK-8745
目录号: A13396
Aurora Kinase A 抑制剂
MK-8745 是一种新型的 Aurora-A 特异性抑制剂。在多种谱系的细胞系中进行体外测试时，它以 p53-依赖的方式诱导细胞凋亡死亡。
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生物活性
| Discription | MK-8745 is a novel Aurora-A specific inhibitor. It induces apoptotic cell death in a p53-dependent manner when tested in vitro in cell lines of multiple lineages. | ||
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产品信息
| 目录号 | A13396 |
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| 分子式 | C20H19ClFN5OS |
| 分子量 | 431.91 |
| CAS号 | 885325-71-3 |
| SMILES | ClC1=C(F)C(C(N2CCN(CC3=NC(NC4=NC=CS4)=CC=C3)CC2)=O)=CC=C1 |
| 其他名称 | MK8745, MK 8745 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 81 mg/mL (187.53 mM) | |
| Water | Insoluble | ||
| Ethanol | 1 mg/mL (2.31 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.15 mL | 115.76 mL | 231.53 mL |
| 0.5 mM | 4.63 mL | 23.15 mL | 46.31 mL |
| 1 mM | 2.32 mL | 11.58 mL | 23.15 mL |
| 5 mM | 0.46 mL | 2.32 mL | 4.63 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 885325-71-3 | 885325-71-3 供应商 | 885325-71-3 花费 | 885325-71-3 生产商 | 订购 885325-71-3 | 885325-71-3 代理商