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MK-8745是一种新的极光特异性抑制剂。当在多种谱系的细胞系中进行体外试验时，它以p53依赖的方式诱导凋亡细胞死亡。
靶点信息
| Aurora A | Aurora B | |||
| 0.6 nM | 280 nM |
| In vitro | DMSO | 81 mg/mL (187.53 mM) | |
| Water | Insoluble | ||
| Ethanol | 1 mg/mL (2.31 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.15 mL | 115.76 mL | 231.53 mL |
| 0.5 mM | 4.63 mL | 23.15 mL | 46.31 mL |
| 1 mM | 2.32 mL | 11.58 mL | 23.15 mL |
| 5 mM | 0.46 mL | 2.32 mL | 4.63 mL |
*The above data is based on the productmolecular weight 431.91. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A13396 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 431.91 |
| Formula | C20H19ClFN5OS |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 885325-71-3 |
| Synonyms | MK8745, MK 8745 |
| SMILES | ClC1=C(F)C(C(N2CCN(CC3=NC(NC4=NC=CS4)=CC=C3)CC2)=O)=CC=C1 |
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