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MKT 077的p53结合位点，并使p53易位至细胞核。选择性细胞毒性；导致培养物中癌细胞生长停滞。也抑制端粒酶活性和交联f-肌动蛋白。
| In vitro | DMSO | 11 mg/mL (25.46 mM) | |
| Water | 75 mg/mL (173.61 mM) | ||
| Ethanol | 9 mg/mL (20.83 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.15 mL | 115.74 mL | 231.48 mL |
| 0.5 mM | 4.63 mL | 23.15 mL | 46.3 mL |
| 1 mM | 2.31 mL | 11.57 mL | 23.15 mL |
| 5 mM | 0.46 mL | 2.31 mL | 4.63 mL |
*The above data is based on the productmolecular weight 432. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12388 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 432 |
| Formula | C21H22ClN3OS2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 147366-41-4 |
| Synonyms | MKT077, MKT-077 |
| SMILES | CCN1/C(=C/C2=CC=CC=[N+]2CC)/S/C(=C/3\N(C4=CC=CC=C4S3)C)/C1=O.[Cl-] |
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