MKT 077
目录号: A12388
HSP70 抑制剂
占据 mortalin-2（mot-2），这是 Hsp70 家族的一个成员，在其 p53 结合位点，并促使 p53 转移到细胞核。选择性细胞毒性；导致培养中的癌细胞生长停滞。还抑制了端粒酶活性，并交联 F-actin。
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生物活性
| Discription | Occupies mortalin-2 (mot-2), a member of the Hsp70 family, at its p53 binding site and enables p53 translocation to the nucleus. Selectively cytotoxic; causes growth arrest of cancer cells in culture. Also inhibits telomerase activity and cross-links F-actin. | |||||
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| Cell Research |
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产品信息
| 目录号 | A12388 |
|---|---|
| 分子式 | C21H22ClN3OS2 |
| 分子量 | 432 |
| CAS号 | 147366-41-4 |
| SMILES | CCN1/C(=C/C2=CC=CC=[N+]2CC)/S/C(=C/3\N(C4=CC=CC=C4S3)C)/C1=O.[Cl-] |
| 其他名称 | MKT077, MKT-077 |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro | DMSO | 11 mg/mL (25.46 mM) | |
| Water | 75 mg/mL (173.61 mM) | ||
| Ethanol | 9 mg/mL (20.83 mM) | ||
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 23.15 mL | 115.74 mL | 231.48 mL |
| 0.5 mM | 4.63 mL | 23.15 mL | 46.3 mL |
| 1 mM | 2.31 mL | 11.57 mL | 23.15 mL |
| 5 mM | 0.46 mL | 2.31 mL | 4.63 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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| 购买 147366-41-4 | 147366-41-4 供应商 | 147366-41-4 花费 | 147366-41-4 生产商 | 订购 147366-41-4 | 147366-41-4 代理商