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ML-3043是p38 MAPK抑制剂（IC50 = 0.38μM）。在外周血单核细胞（PBMC）分析中抑制IL-1β和TNF-α的释放（IC50值分别为0.039和0.16μM）。
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 24.72 mL | 123.61 mL | 247.22 mL |
| 0.5 mM | 4.94 mL | 24.72 mL | 49.44 mL |
| 1 mM | 2.47 mL | 12.36 mL | 24.72 mL |
| 5 mM | 0.49 mL | 2.47 mL | 4.94 mL |
*The above data is based on the productmolecular weight 404.5. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12408 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 404.5 |
| Formula | C23H21FN4S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 549505-65-9 |
| Synonyms | ML3043, ML 3043 |
| SMILES | CC(C1=CC=CC=C1)NC2=NC=CC(=C2)C3=C(NC(=N3)SC)C4=CC=C(C=C4)F |
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