ML-9 hydrochloride

Name: ML-9 hydrochloride
SKU: A17856
Price: 175 CNY
Rating: 5 (288 reviews)

目录号: A17856

MLCK inhibitor

ML-9 是一种选择性且有效的 Akt kinase 抑制剂，能够抑制 myosin light-chain kinase (MLCK) 和 stromal interaction molecule 1 (STIM1) 的活性。ML-9 抑制 MLCK、PKA 和 PKC 的活性，其 Ki 值分别为 4, 32 和 54 微摩尔。ML-9 通过刺激自噬体的形成并抑制其降解来诱导自噬。

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Grouped product items
规格	价格	库存
5mg	¥175.00	现货
10mg	¥315.00	现货
25mg	¥630.00	现货
50mg	¥1,050.00	现货
100mg	¥1,610.00	现货
250mg	¥3,640.00	现货
*10mM 1mL in DMSO**	¥210.00	现货
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Data Sheet

SDS

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生物活性

Discription	ML-9 is a selective and potent inhibitor of Akt kinase, inhibits myosin light-chain kinase (MLCK) and stromal interaction molecule 1 (STIM1) activity. ML-9 inhibits inhibits MLCK, PKA and PKC activity with Ki values of 4, 32 and 54 μM, respectively. ML-9 induces autophagy by stimulating autophagosome formation and inhibiting their degradation.

产品信息

目录号	A17856
分子式	C15H17ClN2O2S.HCl
分子量	361.3
CAS号	105637-50-1
SMILES	Cl.ClC1=C2C=CC=C(C2=CC=C1)S(=O)(=O)N1CCCNCC1
其他名称	ML9
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	70 mg/mL (193.74 mM)
	Water	10 mg/mL (27.67 mM)
	Ethanol	6 mg/mL (16.6 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.68 mL	138.39 mL	276.78 mL
0.5 mM	5.54 mL	27.68 mL	55.36 mL
1 mM	2.77 mL	13.84 mL	27.68 mL
5 mM	0.55 mL	2.77 mL	5.54 mL

Useful Calculator

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Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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