ML221

Name: ML221
SKU: A19446
Price: 315 CNY
Rating: 5 (288 reviews)

目录号: A19446

APJ functional 拮抗剂

ML221 是一种强效的apelin (APJ) 功能性拮抗剂，能够抑制 apelin-13 介导的 APJ 激活，其在 cAMP 检测中的 IC50 为 0.70 微米，在 β-arrestin 检测中的 IC50 为 1.75 微米，而在这两种检测中的 EC80 均为 10 纳米。

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Grouped product items
规格	价格	库存
5mg	¥315.00	现货
10mg	¥490.00	现货
25mg	¥1,120.00	现货
50mg	¥1,750.00	现货
100mg	¥3,220.00	现货
*10mM 1mL in DMSO**	¥315.00	现货
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Data Sheet

SDS

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生物活性

Discription

ML221 is a potent apelin (APJ) functional antagonist, inhibiting apelin-13-mediated activation of APJ, with IC50s of 0.70 μM in the cAMP assay, and 1.75 μM in the β-arrestin assay, and EC80 of 10 nM in both assays.

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A19446
分子式	C17H11N3O6S
分子量	385.35
CAS号	877636-42-5
SMILES	O=C1C=C(CSC2=NC=CC=N2)OC=C1OC(C3=CC=C([N+]([O-])=O)C=C3)=O
其他名称	ML 221, ML-221
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	8 mg/mL (20.76 mM)
	Water	Insoluble
	Ethanol	Insoluble
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	25.95 mL	129.75 mL	259.5 mL
0.5 mM	5.19 mL	25.95 mL	51.9 mL
1 mM	2.6 mL	12.98 mL	25.95 mL
5 mM	0.52 mL	2.6 mL	5.19 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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