MLN2238 (Ixazomib)

Name: MLN2238 (Ixazomib)
SKU: A10600

目录号: A10600

Proteasome 抑制剂

MLN2238 (Ixazomib) Chemical Structure

CAS NO. 1072833-77-2

MLN2238 (Ixazomib)是20S蛋白酶体抑制剂的有效可逆特异性β5位点，IC50值为3.4 nM。

库存：现货

规格	价格	数量
5 mg	￥ 630.00
10 mg	￥ 840.00
50 mg	￥ 2,450.00
100 mg	￥ 4,200.00
10mM * 1mL in DMSO	￥ 630.00

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生物活性

MLN2238 (Ixazomib)是20S蛋白酶体抑制剂的有效可逆特异性β5位点，IC50值为3.4 nM。

靶点信息

20S proteasome (Cell-free assay)	20S proteasome (Cell-free assay)
0.93 nM(Ki)	3.4 nM

溶解度 *

In vitro (25°C)	DMSO	64 mg/mL (177.26 mM)
	Water	Insoluble
	Ethanol	8 mg/mL (22.15 mM)
In vivo	5% DMSO+45% PEG 300+ddH2O	16 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	27.7 mL	138.5 mL	277.01 mL
0.5 mM	5.54 mL	27.7 mL	55.4 mL
1 mM	2.77 mL	13.85 mL	27.7 mL
5 mM	0.55 mL	2.77 mL	5.54 mL

*The above data is based on the productmolecular weight 361.0 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10600
作用机制	Inhibitor (抑制剂)
M. Wt	361.0
Formula	C14H19BCl2N2O4
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1072833-77-2
Synonyms	MLN 2238, MLN-2238
SMILES	B([C@H](CC(C)C)NC(=O)CNC(=O)C1=C(C=CC(=C1)Cl)Cl)(O)O