MLN4924 (Pevonedistat)

Name: MLN4924 (Pevonedistat)
SKU: A11260
Price: 280 CNY
Rating: 5 (9 reviews)

目录号: A11260

NAE 抑制剂

9 篇发表文献

NAE 抑制剂 MLN4924 与 NAE 结合并抑制 NAE，这可能导致抑制肿瘤细胞的增殖和存活。

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Grouped product items
规格	价格	库存
1mg	¥280.00	现货
2mg	¥385.00	现货
5mg	¥595.00	现货
10mg	¥945.00	现货
25mg	¥1,855.00	现货
50mg	¥3,080.00	现货
100mg	¥5,250.00	现货
200mg	¥9,100.00	现货
*10mM 1mL in DMSO**	¥630.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用MLN4924 (Pevonedistat)发表的9篇文献

Takumi Ito, .et al. , Research Square, 2023, 2023

Blue-leaf A. Cordes, .et al. , Cancers (Basel), 2023, Mar; 15(6): 1846 PMID: 36980731

Min Dong, .et al. , J Immunother Cancer, 2022, Oct;10(10):e005270 PMID: 36198437

Corentin Mallet, .et al. , J Virol, 2021, Dec 22;JVI0142721 PMID: 34936483

Nobuyuki Shimizu, .et al. , Commun Biol, 2021, Nov 11;4(1):1277 PMID: 34764413

Jalila Chagraoui, .et al. , Cell Stem Cell, 2021, Jan 7;28(1):48-62.e6 PMID: 33417871

Stephan Riesenberg, .et al. , Nat Commun, 2018, 9: 2164 PMID: 29867139

Hirosumi Tamura, .et al. , Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168

Richard J. Kraus, .et al. , PLoS Pathog, 2017, Jun; 13(6): e1006404 PMID: 28617871

生物活性

Discription

NAE inhibitor MLN4924 binds to and inhibits NAE, which may result in the inhibition of tumor cell proliferation and survival.

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A11260
分子式	C21H25N5O4S
分子量	443.5
CAS号	905579-51-3
SMILES	C1CC2=CC=CC=C2[C@H]1NC3=NC=NC4=C3C=CN4[C@@H]5C[C@H]([C@H](C5)O)COS(=O)(=O)N
其他名称	MLN-4924
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	78 mg/mL (175.86 mM)
	Water	Insoluble
	Ethanol	78 mg/mL
In vivo	5% DMSO+30% PEG 300+5% Tween 80+ddH2O	19 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	22.55 mL	112.74 mL	225.48 mL
0.5 mM	4.51 mL	22.55 mL	45.1 mL
1 mM	2.25 mL	11.27 mL	22.55 mL
5 mM	0.45 mL	2.25 mL	4.51 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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