MLN4924 (Pevonedistat)

目录号: A11260
NAE Inhibitor
NAE 抑制剂 MLN4924 与 NAE 结合并抑制 NAE,这可能导致抑制肿瘤细胞的增殖和存活。
Grouped product items
规格 价格 库存 数量
1mg
¥280.00
现货
2mg
¥385.00
现货
5mg
¥595.00
现货
10mg
¥945.00
现货
25mg
¥1,855.00
现货
50mg
¥3,080.00
现货
100mg
¥5,250.00
现货
200mg
¥9,100.00
现货
10mM * 1mL in DMSO
¥630.00
现货
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重要通知:仅供研究使用。我们不向患者销售。

顾客使用 Adooq 产品发表的高质量科研文献
Adooq用户使用MLN4924 (Pevonedistat)发表的9篇文献
  • Takumi Ito, .et al. , Research Square, 2023, 2023
  • Blue-leaf A. Cordes, .et al. , Cancers (Basel), 2023, Mar; 15(6): 1846 PMID: 36980731
  • Min Dong, .et al. , J Immunother Cancer, 2022, Oct;10(10):e005270 PMID: 36198437
  • Corentin Mallet, .et al. , J Virol, 2021, Dec 22;JVI0142721 PMID: 34936483
  • Nobuyuki Shimizu, .et al. , Commun Biol, 2021, Nov 11;4(1):1277 PMID: 34764413
  • Jalila Chagraoui, .et al. , Cell Stem Cell, 2021, Jan 7;28(1):48-62.e6 PMID: 33417871
  • Stephan Riesenberg, .et al. , Nat Commun, 2018, 9: 2164 PMID: 29867139
  • Hirosumi Tamura, .et al. , Oncol Rep, 2018, Aug; 40(2): 635-646 PMID: 29917168
  • Richard J. Kraus, .et al. , PLoS Pathog, 2017, Jun; 13(6): e1006404 PMID: 28617871
  • 生物活性
    Discription NAE inhibitor MLN4924 binds to and inhibits NAE, which may result in the inhibition of tumor cell proliferation and survival.
    Cell Research
    Cell Line Type Value Description References
    产品信息
    目录号 A11260
    分子式 C21H25N5O4S
    分子量 443.5
    CAS号 905579-51-3
    SMILES C1CC2=CC=CC=C2[C@H]1NC3=NC=NC4=C3C=CN4[C@@H]5C[C@H]([C@H](C5)O)COS(=O)(=O)N
    其他名称 MLN-4924
    储存条件

    Store lyophilized at -20ºC, keep desiccated.
    In lyophilized form, the chemical is stable for 36 months.
    In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

    溶解性数据
    In vitro (25°C) DMSO 78 mg/mL (175.86 mM)
    Water Insoluble
    Ethanol 78 mg/mL
    In vivo 5% DMSO+30% PEG 300+5% Tween 80+ddH2O 19 mg/mL
    * <1 mg/ml means slightly soluble or insoluble.
    * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.
    Preparing Stock Solutions
    Concentration / Solvent Volume / Mass 1 mg 5 mg 10 mg
    0.1 mM 22.55 mL 112.74 mL 225.48 mL
    0.5 mM 4.51 mL 22.55 mL 45.1 mL
    1 mM 2.25 mL 11.27 mL 22.55 mL
    5 mM 0.45 mL 2.25 mL 4.51 mL
    Useful Calculator

    This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

    Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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    Please check COA/MSDS for correct molecular weight.

    Calculate the dilution required to prepare a stock solution.
    This equation is commonly abbreviated as: C1V1 = C2V2

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