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MLN4924 (Pevonedistat)是NAE的小分子抑制剂，是导致肿瘤细胞增殖和存活的抑制剂。
| In vitro (25°C) | DMSO | 78 mg/mL (175.86 mM) | |
| Water | Insoluble | ||
| Ethanol | 78 mg/mL | ||
| In vivo | 5% DMSO+30% PEG 300+5% Tween 80+ddH2O | 19 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.55 mL | 112.74 mL | 225.48 mL |
| 0.5 mM | 4.51 mL | 22.55 mL | 45.1 mL |
| 1 mM | 2.25 mL | 11.27 mL | 22.55 mL |
| 5 mM | 0.45 mL | 2.25 mL | 4.51 mL |
*The above data is based on the productmolecular weight 443.5 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11260 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 443.5 |
| Formula | C21H25N5O4S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 905579-51-3 |
| Synonyms | MLN-4924 |
| SMILES | C1CC2=CC=CC=C2[C@H]1NC3=NC=NC4=C3C=CN4[C@@H]5C[C@H]([C@H](C5)O)COS(=O)(=O)N |
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