MLN8054
目录号: A10601
Aurora A 抑制剂
MLN8054 是一种 Aurora A激酶 抑制剂，能够在体外和体内诱导人类肿瘤细胞的衰老。
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生物活性
| Discription | MLN8054 is an inhibitor of Aurora A kinase, induces senescence in human tumor cells both in vitro and in vivo. | |||||
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产品信息
| 目录号 | A10601 |
|---|---|
| 分子式 | C25H15ClF2N4O2 |
| 分子量 | 476.9 |
| CAS号 | 869363-13-3 |
| SMILES | C1C2=CN=C(N=C2C3=C(C=C(C=C3)Cl)C(=N1)C4=C(C=CC=C4F)F)NC5=CC=C(C=C5)C(=O)O |
| 储存条件 | Store lyophilized at -20ºC, keep desiccated. |
溶解性数据
| In vitro (25°C) | DMSO | 91 mg/mL (190.82 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 15% Captisol | 28 mg/mL | |
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* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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Preparing Stock Solutions
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.97 mL | 104.84 mL | 209.69 mL |
| 0.5 mM | 4.19 mL | 20.97 mL | 41.94 mL |
| 1 mM | 2.1 mL | 10.48 mL | 20.97 mL |
| 5 mM | 0.42 mL | 2.1 mL | 4.19 mL |
Useful Calculator
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2
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