MLN8237 (Alisertib)

Name: MLN8237 (Alisertib)
SKU: A10004

目录号: A10004

Aurora A Kinase 抑制剂

Product Citations (5)

MLN8237 (Alisertib) Chemical Structure

CAS NO. 1028486-01-2

MLN8237 (Alisertib)是一种选择性Aurora A抑制剂，在无细胞分析中的IC50为1.2 nM。它对Aurora A的选择性比Aurora B高200倍以上。

库存：现货

规格	价格	数量
5 mg	￥ 420.00
10 mg	￥ 700.00
50 mg	￥ 1,855.00
200 mg	￥ 5,355.00
10mM * 1mL in DMSO	￥ 560.00

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生物活性

MLN8237 (Alisertib)是一种选择性Aurora A抑制剂，在无细胞分析中的IC50为1.2 nM。它对Aurora A的选择性比Aurora B高200倍以上。

溶解度 *

In vitro (25°C)	DMSO	23 mg/mL (44.32 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5%DMSO+30% PEG300+5%Tween-80+ddH2O	5 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.27 mL	96.36 mL	192.72 mL
0.5 mM	3.85 mL	19.27 mL	38.54 mL
1 mM	1.93 mL	9.64 mL	19.27 mL
5 mM	0.39 mL	1.93 mL	3.85 mL

*The above data is based on the productmolecular weight 518.9. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10004
作用机制	Inhibitor (抑制剂)
M. Wt	518.9
Formula	C27H20ClFN4O4
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1028486-01-2
SMILES	COC1=C(C(=CC=C1)F)C2=NCC3=CN=C(N=C3C4=C2C=C(C=C4)Cl)NC5=CC(=C(C=C5)C(=O)O)OC