MLN8237 (Alisertib)

Name: MLN8237 (Alisertib)
SKU: A10004
Price: 315 CNY
Rating: 5 (7 reviews)

目录号: A10004

Aurora A Kinase 抑制剂

7 篇发表文献

MLN8237（Alisertib）是一种选择性的Aurora A抑制剂，在无细胞试验中的IC50为1.2 nM。它对Aurora A的选择性比Aurora B高出200倍以上。目前处于第三阶段临床试验。

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Grouped product items
规格	价格	库存
5mg	¥315.00	现货
10mg	¥560.00	现货
25mg	¥1,050.00	现货
50mg	¥1,610.00	现货
100mg	¥2,555.00	现货
200mg	¥3,290.00	现货
500mg	¥5,425.00	现货
*10mM 1mL in DMSO**	¥350.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用MLN8237 (Alisertib)发表的7篇文献

Shiang-Jie Yang, .et al. , Cell Death Dis, 2024, Jan 30;15(1):103 PMID: 38291041

Vijaya Bharti, .et al. , Cell Rep, 2022, Dec 20;41(12):111826 PMID: 36543138

Bucko PJ, .et al. , Elife, 2019, Dec 24;8. pii: e52220 PMID: 31872801

Kimura M, .et al. , Exp Cell Res, 2018, Jun 1;367(1):73-80 PMID: 29571950

Jing Wang, .et al. , J Cell Sci, 2017, Mar 15; 130(6): 1078-1093 PMID: 28167680

Lessing D, .et al. , Proc Natl Acad Sci U S A, 2016, Dec 13;113(50):14366-14371 PMID: 28182563

Jennifer M. Sahni, .et al. , J Biol Chem, 2016, Nov 4; 291(45): 23756-23768 PMID: 27650498

生物活性

Discription

MLN8237 (Alisertib) is a selective Aurora A inhibitor with IC50 of 1.2 nM in a cell-free assay. It has >200-fold higher selectivity for Aurora A than Aurora B. Phase 3..

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A10004
分子式	C27H20ClFN4O4
分子量	518.9
CAS号	1028486-01-2
SMILES	COC1=C(C(=CC=C1)F)C2=NCC3=CN=C(N=C3C4=C2C=C(C=C4)Cl)NC5=CC(=C(C=C5)C(=O)O)OC
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro (25°C)	DMSO	23 mg/mL (44.32 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	5%DMSO+30% PEG300+5%Tween-80+ddH2O	5 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.27 mL	96.36 mL	192.72 mL
0.5 mM	3.85 mL	19.27 mL	38.54 mL
1 mM	1.93 mL	9.64 mL	19.27 mL
5 mM	0.39 mL	1.93 mL	3.85 mL

Useful Calculator

This calculator helps you calculate mass of compound based on solution concentration, volume and molecular weight in a specific solution using the formula:

Mass (mg) = Concentration (mM) × Volume (mL) × Molecular Weight (g/mol)

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* Please check COA/MSDS for correct molecular weight.

Calculate the dilution required to prepare a stock solution.
This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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