产品详情

生物活性

MLN9708是一种蛋白酶体抑制剂，可抑制蛋白酶体的活性，从而阻断通常由蛋白酶体进行的靶向蛋白水解。

靶点信息

20S proteasome (Cell-free assay)	20S proteasome (Cell-free assay)
0.93 nM(Ki)	3.4 nM

溶解度 *

In vitro (25°C)	DMSO	85 mg/mL (164.36 mM)
	Water	Insoluble
	Ethanol	Insoluble
In vivo	0.5% hydroxyethyl cellulose	28 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	19.34 mL	96.69 mL	193.39 mL
0.5 mM	3.87 mL	19.34 mL	38.68 mL
1 mM	1.93 mL	9.67 mL	19.34 mL
5 mM	0.39 mL	1.93 mL	3.87 mL

*The above data is based on the productmolecular weight 517.1 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10602
作用机制	Inhibitor (抑制剂)
M. Wt	517.1
Formula	C20H23BCl2N2O9
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1201902-80-8
Synonyms	MLN-9708
SMILES	B1(OC(=O)CC(O1)(CC(=O)O)C(=O)O)[C@H](CC(C)C)NC(=O)CNC(=O)C2=C(C=CC(=C2)Cl)Cl