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Monastrol是一种有效的，细胞可渗透的非微管蛋白相互作用的有丝分裂抑制剂。Monastrol通过与有丝分裂驱动蛋白Eg5结合来阻断有丝分裂（IC50 = 14μM），Eg5是纺锤体双极性所必需的运动蛋白。
| In vitro | DMSO | 54 mg/mL (184.71 mM) | |
| Water | Insoluble | ||
| Ethanol | 54 mg/mL (184.71 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 34.2 mL | 171 mL | 342 mL |
| 0.5 mM | 6.84 mL | 34.2 mL | 68.4 mL |
| 1 mM | 3.42 mL | 17.1 mL | 34.2 mL |
| 5 mM | 0.68 mL | 3.42 mL | 6.84 mL |
*The above data is based on the productmolecular weight 292.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11976 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 292.4 |
| Formula | C14H16N2O3S |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 329689-23-8 |
| SMILES | CCOC(=O)C1=C(NC(=S)NC1C2=CC(=CC=C2)O)C |
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