Monomethyl auristatin E

Name: Monomethyl auristatin E
SKU: A12954
Price: 175 CNY
Rating: 5 (1 reviews)

目录号: A12954

1 篇发表文献

单甲基奥里司他 (MMAE) 是一种抗有丝分裂剂，它通过阻断微管蛋白的聚合来抑制细胞分裂，并且还显示出对抗体-药物偶联物（ADCs）活性的抑制。

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Grouped product items
规格	价格	库存
5mg	¥175.00	现货
10mg	¥245.00	现货
25mg	¥385.00	现货
50mg	¥595.00	现货
100mg	¥1,120.00	现货
250mg	¥1,820.00	现货
500mg	¥2,730.00	现货
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Data Sheet

SDS

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Adooq用户使用Monomethyl auristatin E发表的1篇文献

Sochaj-Gregorczyk AM, .et al. , J Immunother, 2016, Jul-Aug;39(6):223-32 PMID: 27227324

生物活性

Discription

Monomethyl auristatin E (MMAE) is an antimitotic agent which inhibits cell division by blocking the polymerisation of tubulin, and also shows inhibition of antibody-drug conjugates (ADCs) activity.

Targets

Target	Value

Cell Research

Cell Line	Type	Value	Description	References

产品信息

目录号	A12954
分子式	C39H67N5O7
分子量	717.98
CAS号	474645-27-7
SMILES	CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@H](C)[C@H](C2=CC=CC=C2)O)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC
其他名称	Monomethylauristatin E, MMAE
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	93 mg/mL (129.52 mM)
	Water	Insoluble
	Ethanol	93 mg/mL (129.52 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	13.93 mL	69.64 mL	139.28 mL
0.5 mM	2.79 mL	13.93 mL	27.86 mL
1 mM	1.39 mL	6.96 mL	13.93 mL
5 mM	0.28 mL	1.39 mL	2.79 mL

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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