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Monomethyl auristatin E是一种抗有丝分裂剂，可通过阻止微管蛋白的聚合来抑制细胞分裂，并且还表现出对抗体-药物偶联物（ADCs）活性的抑制作用。
| In vitro | DMSO | 93 mg/mL (129.52 mM) | |
| Water | Insoluble | ||
| Ethanol | 93 mg/mL (129.52 mM) | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 13.93 mL | 69.64 mL | 139.28 mL |
| 0.5 mM | 2.79 mL | 13.93 mL | 27.86 mL |
| 1 mM | 1.39 mL | 6.96 mL | 13.93 mL |
| 5 mM | 0.28 mL | 1.39 mL | 2.79 mL |
*The above data is based on the productmolecular weight 717.98. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12954 |
|---|---|
| 作用机制 | Stimulator (刺激物) |
| M. Wt | 717.98 |
| Formula | C39H67N5O7 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 474645-27-7 |
| Synonyms | Monomethylauristatin E, MMAE |
| SMILES | CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@@H]([C@@H](C)C(=O)N[C@H](C)[C@H](C2=CC=CC=C2)O)OC)OC)N(C)C(=O)[C@H](C(C)C)NC(=O)[C@H](C(C)C)NC |
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