Motesanib (AMG706)

Name: Motesanib (AMG706)
SKU: A11496
Price: 210 CNY
Rating: 5 (1 reviews)

目录号: A11496

VEGFR 抑制剂

1 篇发表文献

Motesanib（AMG706）是一种多激酶抑制剂，它选择性地针对VEGF受体、血小板源生长因子受体（PDGFRs）和Kit受体，其IC50值分别为2 nM（VEGFR1）、3 nM（VEGFR2）、6 nM（VEGFR3）、84 nM（PDGFR）和8 nM（Kit）。

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Grouped product items
规格	价格	库存
5mg	¥210.00	现货
10mg	¥315.00	现货
25mg	¥595.00	现货
50mg	¥1,050.00	现货
100mg	¥1,505.00	现货
*10mM 1mL in DMSO**	¥315.00	现货
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重要通知：仅供研究使用。我们不向患者销售。

Data Sheet

SDS

顾客使用 Adooq 产品发表的高质量科研文献

Adooq用户使用Motesanib (AMG706)发表的1篇文献

Ayaka Kojima, .et al. , Xenobiotica, 2022, Jul;52(7):669-675 PMID: 36251932

生物活性

Discription

Motesanib (AMG706) is a multikinase inhibitor that selectively targets VEGF receptors, platelet-derived growth factor receptors (PDGFRs), and Kit receptors with IC?? values of 2 nM (VEGFR1), 3 nM (VEGFR2), 6 nM (VEGFR3), 84 nM (PDGFR), and 8 nM (Kit).

Targets

Target	Value

产品信息

目录号	A11496
分子式	C22H23N5O
分子量	373.45
CAS号	453562-69-1
SMILES	CC1(CNC2=C1C=CC(=C2)NC(=O)C3=C(N=CC=C3)NCC4=CC=NC=C4)C
其他名称	AMG 706, AMG-706
储存条件	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.

溶解性数据

In vitro	DMSO	68 mg/mL (182.09 mM)
	Water	Insoluble
	Ethanol	7 mg/mL (18.74 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

Preparing Stock Solutions

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	26.78 mL	133.89 mL	267.77 mL
0.5 mM	5.36 mL	26.78 mL	53.55 mL
1 mM	2.68 mL	13.39 mL	26.78 mL
5 mM	0.54 mL	2.68 mL	5.36 mL

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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