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Mps1 inhibitor
AZ 3146 是一种强效且选择性的单极纺锤体1 (Mps1) 激酶抑制剂（IC50 = 35 nM）。它干扰染色体排列，并能绕过纺锤体组装检查点，同时抑制 Mad1、Mad2 和着丝粒蛋白E (CENP-E) 的招募到着丝粒。- Junna Tanaka, .et al. , Cell Signal, 2024, Jul:119:111172 PMID: 38604342
- Ryuzaburo Yuki, .et al. , Eur J Pharmacol, 2024, Jan 15:963:176229 PMID: 38072041
- Ryoko Ota, .et al. , Cell Signal, 2023, Sep;109:110764 PMID: 37315749
- Ryuzaburo Yuki, .et al. , J Cell Mol Med, 2021, Feb;25(3):1677-1687 PMID: 33465289
- Yamagishi A, .et al. , Int J Mol Sci, 2020, Feb 5;21(3) PMID: 32033461
- Kakihana A, .et al. , FASEB J, 2018, Nov 29:fj201801369R PMID: 30496702
- Suzuki M, .et al. , Anticancer Res, 2016, Jun;36(6):2783-92 PMID: 27272789
