产品详情

生物活性

MS023是PRMT 1、3、4、6和8（IC50分别为30、119、83、8和8 nM）的有效抑制剂，它们负责精氨酸残基的不对称二甲基化。

靶点信息

PRMT6	PRMT8	PRMT1	PRMT4	PRMT3
4 nM	5 nM	30 nM	83 nM	119 nM

溶解度 *

In vitro	DMSO	50 mg/mL (173.96 mM)
	Water	Insoluble
	Ethanol	50 mg/mL (173.96 mM)
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	34.79 mL	173.97 mL	347.95 mL
0.5 mM	6.96 mL	34.79 mL	69.59 mL
1 mM	3.48 mL	17.4 mL	34.79 mL
5 mM	0.7 mL	3.48 mL	6.96 mL

*The above data is based on the productmolecular weight 287.4. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A12585
作用机制	Inhibitor (抑制剂)
M. Wt	287.4
Formula	C17H25N3O
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	1831110-54-3
Synonyms	MS-023, MS 023
SMILES	NCCN(C)CC1=CNC=C1C2=CC=C(OC(C)C)C=C2