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MSX-122是口服可生物利用的CXCR4抑制剂（IC50 =?10 nM），具有潜在的抗肿瘤和抗病毒活性。CXCR4抑制剂MSX-122与趋化因子受体CXCR4结合，阻止基质衍生因子-1（SDF-1）与CXCR4受体和受体激活结合，这可能导致肿瘤细胞增殖和迁移减少。
| In vitro | DMSO | 3 mg/mL (10.26 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
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| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 34.21 mL | 171.03 mL | 342.07 mL |
| 0.5 mM | 6.84 mL | 34.21 mL | 68.41 mL |
| 1 mM | 3.42 mL | 17.1 mL | 34.21 mL |
| 5 mM | 0.68 mL | 3.42 mL | 6.84 mL |
*The above data is based on the productmolecular weight 292.34. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A12596 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 292.34 |
| Formula | C16H16N6 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 897657-95-3 |
| Synonyms | MSX122, MSX 122 |
| SMILES | C1=CN=C(N=C1)NCC2=CC=C(C=C2)CNC3=NC=CC=N3 |
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