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￥ 0.00 mTOR
| Catalog No. | Inhibitor Name | mTOR | mTORC1 | mTORC2 | Other Targets |
|---|---|---|---|---|---|
| A10133 | Dactolisib | *** | p110α,p110γ,p110δ | ||
| A10782 | Rapamycin | **** | |||
| A10374 | Everolimus | *** | |||
| A10114 | AZD8055 | **** | DNA-PK,PI3Kδ,PI3Kα | ||
| A10906 | Temsirolimus | * | |||
| A10726 | PI-103 | * | p110α,p110δ,p110β | ||
| A10505 | KU-0063794 | ** | ** | ||
| A10746 | Torkinib | ** | p110δ,PDGFR,DNA-PK | ||
| A10295 | Ridaforolimus | **** | |||
| A11461 | INK 128 | **** | PI3Kα,PI3Kγ,PI3Kδ | ||
| A10997 | Voxtalisib Analogue | * | PI3Kγ,PI3Kα,PI3Kδ | ||
| A11587 | Torin 1 | *** | *** | ** | DNA-PK,p110γ,C2α |
| A11035 | Omipalisib | **** | **** | p110α,p110δ,p110γ | |
| A11056 | OSI-027 | *** | * | * | PI3Kγ,DNA-PK,PI3Kα |
| A11024 | PF-04691502 | ** | PI3Kδ,PI3Kα,PI3Kγ | ||
| A11023 | Apitolisib | * | p110α,p110δ,p110γ | ||
| A10438 | GSK1059615 | ** | PI3Kα,PI3Kβ,PI3Kδ | ||
| A11079 | Gedatolisib | **** | PI3Kα,PI3Kγ | ||
| A10989 | WYE-354 | *** | PI3Kα,PI3Kγ | ||
| A11303 | Vistusertib | *** | P-Akt (S473),pS6 (S235/236) | ||
| A11586 | Torin 2 | **** | ATM,ATR,DNA-PK | ||
| A11038 | WYE-125132 | **** | |||
| A11207 | PP121 | ** | PDGFR,Hck,VEGFR | ||
| A11187 | WYE-687 | *** | PI3Kα,PI3Kγ,p38α | ||
| A11169 | CH5132799 | * | PI3Kα,PI3Kγ,PI3Kβ | ||
| A11188 | WAY-600 | ** | PI3Kα,PI3Kγ | ||
| A13328 | ETP-46464 | **** | ATR,DNA-PK,PI3Kα | ||
| A11443 | GDC-0349 | *** | PI3Kα | ||
| A12395 | XL388 | ** | ** | * | CYP2C9,CYP3A4 |
| A13078 | CC-223 | ** | cFMS,FLT4,DNA-PK | ||
| A16276 | Voxtalisib | * | PI3Kγ,PI3Kα,PI3Kδ | ||
| A11950 | Zotarolimus | *** | |||
| A10389 | Tacrolimus | ||||
| A11162 | BGT226 | PI3Kα,PI3Kγ,PI3Kβ | |||
| A10693 | Palomid 529 | ||||
| A10210 | Chrysophanic Acid | EGFR | |||
| A11537 | QL-IX-55 | ||||
| A12480 | VS-5584 | **** | PI3Kα, PI3Kδ, PI3Kγ, PI3Kβ | ||
| A12704 | SF1126 | PI3K | |||
| A12935 | PF-04979064 | **** | PI3Kα, PI3Kδ, PI3Kγ, PI3Kβ, Akt | ||
| A14432 | GNE-493 | *** | PI3Kα, PI3Kδ, PI3Kγ, PI3Kβ | ||
| A15175 | mTOR inhibitor (mTOR-IN-1) | *** | |||
| A15508 | MHY1485 | ||||
| A16126 | LY3023414 | PI3Kα, Akt1, DNA-PK |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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VS-5584
Catalog No. A12480 -
Torin 1
Catalog No. A11587 -
mTOR inhibitor (mTOR-IN-1)
Catalog No. A15175 -
MHY1485
Catalog No. A15508 -
AZD2014 (Vistusertib)
Catalog No. A11303 mTORC1/2 抑制剂Vistusertib (AZD2014)是一种新型mTOR抑制剂，无细胞试验中IC50为2.8 nM；对多种PI3K亚型(α/β/γ/δ)具有较高选择性。浓度为1 μM时，对大多数激酶无或有微弱结合力。 了解更多 -
FK-506 (Tacrolimus)
Catalog No. A10389 mTOR 抑制剂FK-506 (Tacrolimus)是一种免疫抑制药物，通过结合到抑免蛋白FKBP12 (FK506 结合蛋白)产生新的复合物，从而降低T细胞中肽酰脯氨酰异构酶活性。 了解更多 -
SAR245409 (XL765, Voxtalisib)
Catalog No. A16276 PI3K/mTOR dual 抑制剂SAR245409 (XL765,Voxtalisib)是PI3K/mTOR双激酶抑制剂XL765是口服生物可利用的小分子，靶向PI3K/mTOR信号途径中的磷脂酰肌醇3激酶（PI3K）和雷帕霉素（mTOR）激酶的哺乳动物靶标，具有潜在的抗肿瘤活性。 了解更多 -
GSK2126458 (Omipalisib)
Catalog No. A11035 mTOR/PI3K 抑制剂,GSK2126458 (Omipalisib)是一种高选择性的，有效的p110α/β/γ/δ和 mTORC1/2抑制剂，无细胞试验中Ki分别为0.019 nM/0.13 nM/0.024 nM/0.06 nM和0.18 nM/0.3 nM。 了解更多 -
BEZ235 (NVP-BEZ235, Dactolisib)
Catalog No. A10133 PI3K/mTOR 抑制剂BEZ235 (NVP-BEZ235,Dactolisib)是通过与这些酶的ATP结合裂隙结合来抑制PI3K和mTOR激酶活性。 了解更多 -
Rapamycin (Sirolimus)
Catalog No. A10782 mTOR 抑制剂Rapamycin (Sirolimus)是通过抑制T细胞和B细胞对白介素2（IL-2）的反应来防止其活化。 了解更多 -
GSK1059615
Catalog No. A10438 mTOR/PI3K 抑制剂GSK1059615是PI3Kα (IC50 = 2 nM)的强效、可逆、ATP竞争性噻唑烷二酮抑制剂。 了解更多 -
Everolimus (RAD001)
Catalog No. A10374 mTOR 抑制剂Everolimus (RAD001)是西罗莫司的40-O-(2-羟乙基)衍生物，与西罗莫司作为mTOR抑制剂的作用相似。 了解更多 -
GDC-0980 (Apitolisib, RG7422)
Catalog No. A11023 mTOR/PI3K 抑制剂GDC-0980 (Apitolisib,RG7422)是一种有效的，I型PI3激酶和mTOR激酶抑制剂（TORC1/2），对于p110α，β，δ和γ的体外IC50为5、27、7和14 nM。 了解更多 -
PF-04691502
Catalog No. A11024 PI3K/mTOR 抑制剂PF-04691502是PI3K/mTOR激酶抑制剂，也是在PI3K/mTOR信号传导途径中靶向磷脂酰肌醇3激酶（PI3K）和雷帕霉素（mTOR）哺乳动物靶标的药物。 了解更多 -
Desmethyl-VS-5584
Catalog No. A10900 -
CC-115
Catalog No. A15779 -
Dactolisib Tosylate
Catalog No. A11327 dual PI3K and mTOR kinase inhibitorDactolisib Tosylate (BEZ235 Tosylate) is a dual PI3K and mTOR kinase inhibitor with IC50 values of 4, 75, 7, 5 nM for PI3Kα, β, γ, δ, respectively. Dactolisib Tosylate (BEZ235 Tosylate) inhibits mTORC1 and mTORC2. 了解更多 -
mTOR inhibitor-2
Catalog No. A13035 mTOR inhibitormTOR inhibitor-2 is a highlt potent, selective and oral mTOR inhibitor with an IC50 of 7 nM. mTOR inhibitor-2 inhibits cellular phosphorylation of mTORC1 (pS6 and p4E-BP1) and mTORC2 (pAKT (S473)) substrates. 了解更多 -
HDACs/mTOR Inhibitor 1
Catalog No. A13462 HDACs/mTOR Inhibitor 1HDACs/mTOR Inhibitor 1 is a dual Histone Deacetylases (HDACs) and mammalian target of Rapamycin (mTOR) target inhibitor for treating hematologic malignancies. 了解更多 -
LY 303511
Catalog No. A15147 -
GNE-493
Catalog No. A14432 -
GNE 477
Catalog No. A14114 -
42-(2-Tetrazolyl)rapamycin
Catalog No. A21394 mTOR inhibitor42-(2-Tetrazolyl)rapamycin is a prodrug compound of a rapamycin analog extracted from patent US 20080171763 A1, Example 1. Rapamycin is a specific mTOR inhibitor. 了解更多 -
Temsirolimus (Torisel)
Catalog No. A10906 -
KU-0063794
Catalog No. A10505 -
Palomid 529 (P529)
Catalog No. A10693 -
WYE-125132 (WYE-132)
Catalog No. A11038 mTOR 抑制剂WYE-125132 (WYE-132)是一种高度有效的，ATP竞争性的mTOR抑制剂，IC50为0.19 nM；作用于mTOR比作用于PI3Ks或PI3K相关激酶hSMG1和ATR选择性高。 了解更多 -
XL765
Catalog No. A10997 -
OSI-027
Catalog No. A11056 -
PKI-587 ( Gedatolisib )
Catalog No. A11079 PI3K/mTOR 抑制剂PKI-587 (Gedatolisib)是一种高效的PI3K/mTOR激酶抑制剂，可抑制PI3K-α，β，γ，δ亚型和mTOR，IC50分别为0.4、6.0、5.4、6.0和1.6 nM。 了解更多 -
NVP-BGT226
Catalog No. A11162 PI3K 抑制剂NVP-BGT226，新型磷酸肌醇3-激酶/mTOR双重抑制剂，作用于PI3Kα/β/γ，IC50为4 nM/63 nM/38 nM，在体外和体内对人的头颈癌细胞均显示出强大的生长抑制活性。 了解更多 -
Deforolimus (Ridaforolimus)
Catalog No. A10295 mTOR 抑制剂Deforolimus (Ridaforolimus)是mTOR蛋白的研究目标靶向小分子抑制剂。阻断mTOR通过干扰细胞生长，分裂，代谢和血管生成，在癌细胞中产生饥饿样的效应。 了解更多 -
INK 128 (MLN0128)
Catalog No. A11461 mTOR 抑制剂INK 128是TORC1/2抑制剂，也是具有潜在抗肿瘤活性的猛禽mTOR（TOR复合物1或TORC1）和raptor-mTOR（TOR复合物2或TORC2）的口服生物利用抑制剂。 了解更多 -
Zotarolimus
Catalog No. A11950 mTOR 抑制剂Zotarolimus是一种免疫抑制剂，可以抑制FKBP-12结合的IC50为2.8nM。。它是雷帕霉素的半合成衍生物。它设计用于以磷酸胆碱为载体的支架。 了解更多