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￥ 0.00 mTOR
| Catalog No. | Inhibitor Name | mTOR | mTORC1 | mTORC2 | Other Targets |
|---|---|---|---|---|---|
| A10133 | Dactolisib | *** | p110α,p110γ,p110δ | ||
| A10782 | Rapamycin | **** | |||
| A10374 | Everolimus | *** | |||
| A10114 | AZD8055 | **** | DNA-PK,PI3Kδ,PI3Kα | ||
| A10906 | Temsirolimus | * | |||
| A10726 | PI-103 | * | p110α,p110δ,p110β | ||
| A10505 | KU-0063794 | ** | ** | ||
| A10746 | Torkinib | ** | p110δ,PDGFR,DNA-PK | ||
| A10295 | Ridaforolimus | **** | |||
| A11461 | INK 128 | **** | PI3Kα,PI3Kγ,PI3Kδ | ||
| A10997 | Voxtalisib Analogue | * | PI3Kγ,PI3Kα,PI3Kδ | ||
| A11587 | Torin 1 | *** | *** | ** | DNA-PK,p110γ,C2α |
| A11035 | Omipalisib | **** | **** | p110α,p110δ,p110γ | |
| A11056 | OSI-027 | *** | * | * | PI3Kγ,DNA-PK,PI3Kα |
| A11024 | PF-04691502 | ** | PI3Kδ,PI3Kα,PI3Kγ | ||
| A11023 | Apitolisib | * | p110α,p110δ,p110γ | ||
| A10438 | GSK1059615 | ** | PI3Kα,PI3Kβ,PI3Kδ | ||
| A11079 | Gedatolisib | **** | PI3Kα,PI3Kγ | ||
| A10989 | WYE-354 | *** | PI3Kα,PI3Kγ | ||
| A11303 | Vistusertib | *** | P-Akt (S473),pS6 (S235/236) | ||
| A11586 | Torin 2 | **** | ATM,ATR,DNA-PK | ||
| A11038 | WYE-125132 | **** | |||
| A11207 | PP121 | ** | PDGFR,Hck,VEGFR | ||
| A11187 | WYE-687 | *** | PI3Kα,PI3Kγ,p38α | ||
| A11169 | CH5132799 | * | PI3Kα,PI3Kγ,PI3Kβ | ||
| A11188 | WAY-600 | ** | PI3Kα,PI3Kγ | ||
| A13328 | ETP-46464 | **** | ATR,DNA-PK,PI3Kα | ||
| A11443 | GDC-0349 | *** | PI3Kα | ||
| A12395 | XL388 | ** | ** | * | CYP2C9,CYP3A4 |
| A13078 | CC-223 | ** | cFMS,FLT4,DNA-PK | ||
| A16276 | Voxtalisib | * | PI3Kγ,PI3Kα,PI3Kδ | ||
| A11950 | Zotarolimus | *** | |||
| A10389 | Tacrolimus | ||||
| A11162 | BGT226 | PI3Kα,PI3Kγ,PI3Kβ | |||
| A10693 | Palomid 529 | ||||
| A10210 | Chrysophanic Acid | EGFR | |||
| A11537 | QL-IX-55 | ||||
| A12480 | VS-5584 | **** | PI3Kα, PI3Kδ, PI3Kγ, PI3Kβ | ||
| A12704 | SF1126 | PI3K | |||
| A12935 | PF-04979064 | **** | PI3Kα, PI3Kδ, PI3Kγ, PI3Kβ, Akt | ||
| A14432 | GNE-493 | *** | PI3Kα, PI3Kδ, PI3Kγ, PI3Kβ | ||
| A15175 | mTOR inhibitor (mTOR-IN-1) | *** | |||
| A15508 | MHY1485 | ||||
| A16126 | LY3023414 | PI3Kα, Akt1, DNA-PK |
Notes:
1.Hover mouse over "" to view the IC50 value.(A few compounds have proven potency but without published IC50 data.)
2.For more details about the compound, click on the product name of your interest.
3.The higher the number of "" is, the more potent the inhibitor or activator is.
4."" refers to compounds which do inhibitory effects on the related isoform, but without specific value.
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Torin 1
Catalog No. A11587 -
AZD2014 (Vistusertib)
Catalog No. A11303 mTORC1/2 抑制剂Vistusertib (AZD2014)是一种新型mTOR抑制剂，无细胞试验中IC50为2.8 nM；对多种PI3K亚型(α/β/γ/δ)具有较高选择性。浓度为1 μM时，对大多数激酶无或有微弱结合力。 了解更多 -
FK-506 (Tacrolimus)
Catalog No. A10389 mTOR 抑制剂FK-506 (Tacrolimus)是一种免疫抑制药物，通过结合到抑免蛋白FKBP12 (FK506 结合蛋白)产生新的复合物，从而降低T细胞中肽酰脯氨酰异构酶活性。 了解更多