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Mutant IDH1-IN-1 is a mutant-selective IDH1 inhibitor with with IC50s of 4, 42, 80 and 143 nM against mutant IDH1 R132C/R132C, IDH1 R132H/R132H, IDH1 R132H/WT and wild type IDH1, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 20.06 mL | 100.28 mL | 200.57 mL |
| 0.5 mM | 4.01 mL | 20.06 mL | 40.11 mL |
| 1 mM | 2.01 mL | 10.03 mL | 20.06 mL |
| 5 mM | 0.4 mL | 2.01 mL | 4.01 mL |
*The above data is based on the productmolecular weight 498.59. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A21359 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 498.59 |
| Formula | C30H31FN4O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1355326-21-4 |
| SMILES | O=C(C(C1=C(C)C=CC=C1)N(C(CN2C=NC3=C2C=CC=C3)=O)C4=CC(F)=CC=C4)NC5CCCCC5 |
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