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Mutant IDH1-IN-4 (compound 434) is an inhibitor of mutant Isocitrate dehydrogenase 1 (IDH 1), with IC50 values of ?? 0.5 μM for mutant IDH1 in R132H, HT1080 and U87R132H cells.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.8 mL | 114.01 mL | 228.02 mL |
| 0.5 mM | 4.56 mL | 22.8 mL | 45.6 mL |
| 1 mM | 2.28 mL | 11.4 mL | 22.8 mL |
| 5 mM | 0.46 mL | 2.28 mL | 4.56 mL |
*The above data is based on the productmolecular weight 438.56. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A19106 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 438.56 |
| Formula | C25H34N4O3 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 1416270-18-2 |
| SMILES | N#CC1=C(N2C[C@@H](C3CC3)N(C(CCOC)=O)CC2)N=C(C4CC4)C5=C1CC(C)(C)OC5 |
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