Nampt-IN-3
目录号: A19769
NAMPT inhibitor
Nampt-IN-3(化合物35)同时抑制烟酰胺磷酸核糖转移酶(NAMPT)和组蛋白去乙酰化酶(HDAC),其半抑制浓度(IC50)分别为31纳摩尔和55纳摩尔。Nampt-IN-3有效诱导细胞凋亡和自噬,并最终导致细胞死亡。
Discription | Nampt-IN-3 (Compound 35) simultaneously inhibit nicotinamide phosphoribosyltransferase (NAMPT) and HDAC with IC50s of 31 nM and 55 nM, respectively. Nampt-IN-3 effectively induces cell apoptosis and autophagy and ultimately leads to cell death. | |||||
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Cell Research |
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目录号 | A19769 |
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分子式 | C29H25N7O2 |
分子量 | 503.55 |
CAS号 | 2121591-52-2 |
SMILES | O=C(C1=CC=C(C2=CN(CC3=CC=C(C(NC4=CC=CC=C4N)=O)C=C3)N=N2)C=C1)NCC5=CC=CN=C5 |
储存条件 | Store lyophilized at -20ºC, keep desiccated. |
Calculate the dilution required to prepare a stock solution. This equation is commonly abbreviated as: C1V1 = C2V2