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Necrostatin-1是一种与ATP竞争的，与受体相互作用的蛋白激酶1（RIPK1）的变构抑制剂（EC50 = 182 nM）。
靶点信息
| RIP1 (293T cells) | ||||
| 490 nM(EC50) |
| In vitro (25°C) | DMSO | Warmed: 43 mg/mL (165.81 mM) | |
| Water | Insoluble | ||
| Ethanol | Insoluble | ||
| In vivo | 5% DMSO+45% PEG 300+ddH2O | 9 mg/mL | |
|
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations. |
|||
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 38.56 mL | 192.8 mL | 385.61 mL |
| 0.5 mM | 7.71 mL | 38.56 mL | 77.12 mL |
| 1 mM | 3.86 mL | 19.28 mL | 38.56 mL |
| 5 mM | 0.77 mL | 3.86 mL | 7.71 mL |
*The above data is based on the productmolecular weight 259.33. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A11973 |
|---|---|
| 作用机制 | Inhibitor (抑制剂) |
| M. Wt | 259.33 |
| Formula | C13H13N3OS |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 4311-88-0 |
| SMILES | CN1C(=O)C(NC1=S)CC2=CNC3=CC=CC=C32 |
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