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Nelarabine (Arranon)

Nelarabine (Arranon)

Name: Nelarabine (Arranon)
SKU: A10632

目录号: A10632

Nelarabine (Arranon) Chemical Structure

CAS NO. 121032-29-9

Nelarabine是一种嘌呤核苷类似物，可转化为其相应的阿拉伯糖基鸟嘌呤核苷酸三磷酸（araGTP），从而抑制DNA合成和细胞毒性，IC50为0.067-2.15 μM。

库存：现货

规格	价格	数量
5 mg	￥ 490.00
10 mg	￥ 840.00
50 mg	￥ 2,800.00
100 mg	￥ 4,060.00
10mM * 1mL in DMSO	￥ 560.00

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生物活性

Nelarabine是一种嘌呤核苷类似物，可转化为其相应的阿拉伯糖基鸟嘌呤核苷酸三磷酸（araGTP），从而抑制DNA合成和细胞毒性，IC50为0.067-2.15 μM。

靶点信息

DNA synthesis (PER-255 cells)	DNA synthesis (HSB2 cells)	DNA synthesis (ALL-SIL cells)	DNA synthesis (JURKAT cells)
67 nM	0.44 μM	1.24 μM	2.15 μM

溶解度 *

In vitro (25°C)	DMSO	55 mg/mL (185.01 mM)
	Water	3 mg/mL (10.09 mM)
	Ethanol	Insoluble
In vivo	saline	2 mg/mL
* <1 mg/ml means slightly soluble or insoluble. * Please note that Adooq tests the solubility of all compounds in-house, and the actual solubility may differ slightly from published values. This is normal and is due to slight batch-to-batch variations.

制备储备液

Concentration / Solvent Volume / Mass	1 mg	5 mg	10 mg
0.1 mM	33.64 mL	168.18 mL	336.36 mL
0.5 mM	6.73 mL	33.64 mL	67.27 mL
1 mM	3.36 mL	16.82 mL	33.64 mL
5 mM	0.67 mL	3.36 mL	6.73 mL

*The above data is based on the productmolecular weight 297.3 . Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.

化学数据

目录号	A10632
M. Wt	297.3
Formula	C11H15N5O5
Purity	>99%
Storage	Store lyophilized at -20ºC, keep desiccated. In lyophilized form, the chemical is stable for 36 months. In solution, store at -20ºC and use within 3 months to prevent loss of potency. Aliquot to avoid multiple freeze/thaw cycles.
CAS No.	121032-29-9
Synonyms	506U78
SMILES	COC1=NC(=NC2=C1N=CN2[C@H]3[C@H]([C@@H]([C@H](O3)CO)O)O)N