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Nelotanserin is a potent 5-HT2A inverse agonist, a moderately potent 5-HT2C partial inverse agonist and a weak 5-HT2B inverse agonist, with IC50s of 1.7, 79, 791 nM in IP accumulation assays, respectively.
| Concentration / Solvent Volume / Mass | 1 mg | 5 mg | 10 mg |
|---|---|---|---|
| 0.1 mM | 22.87 mL | 114.35 mL | 228.71 mL |
| 0.5 mM | 4.57 mL | 22.87 mL | 45.74 mL |
| 1 mM | 2.29 mL | 11.44 mL | 22.87 mL |
| 5 mM | 0.46 mL | 2.29 mL | 4.57 mL |
*The above data is based on the productmolecular weight 437.24. Batch specific molecular weights may vary from batch to batch due to solvent of hydration, which will affect the solvent volumes required to prepare stock solutions.
| 目录号 | A21506 |
|---|---|
| 作用机制 | Agonist (激动剂) |
| M. Wt | 437.24 |
| Formula | C18H15BrF2N4O2 |
| Purity | >99% |
| Storage | Store lyophilized at -20ºC, keep desiccated. |
| CAS No. | 839713-36-9 |
| Synonyms | APD125, APD 125, APD-125 |
| SMILES | COC1=C(C2=C(Br)C=NN2C)C=C(NC(NC3=C(F)C=C(F)C=C3)=O)C=C1 |
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