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Neuronal Signaling

Neuronal Signaling

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ARN2966

Catalog No. A21016
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APP expression modulator

ARN2966 is a potent post-transcriptional modulator of APP expression; reduces expression of APP with resultant lower production of Aβ. 了解更多

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Compound W

Catalog No. A15296
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Gamma-secretase modulator

Compound W是一种γ-分泌酶抑制剂，已被证明可以降低分泌的Aβ42和Nβ25的水平。了解更多

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CHF5074

Catalog No. A16214
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γ-Secretase modulator

CHF5074是新型的γ-分泌酶调节剂，可减少Aβ42和Aβ40的分泌，IC50分别为3.6和18.4 uM。了解更多

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gamma-secretase modulator 2

Catalog No. A11427
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Gamma-secretase modulator

Gamma-secretase modulator 2是γ-secretase调节剂，可用于阿尔兹海默。了解更多

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Flurizan

Catalog No. A12433
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gamma-secretase modulator

Flurizan是一种非甾体抗炎药（NSAID），可抑制γ-分泌酶的活性。了解更多

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E 2012

Catalog No. A11393
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gamma-secretase modulator

E 2012是γ-secretase抑制剂。了解更多

Product Citations (1)

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- Yesuvadian R, .et al. Potent γ-secretase inhibitors/modulators interact with amyloid-β fibrils but do not inhibit fibrillation: a high-resolution NMR study., Biochem Biophys Res Commun., 2014, May 16;447(4):590-5 PMID: 24747079
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gamma-secretase modulator 3

Catalog No. A15090
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gamma-secretase modulator

gamma-secretase modulator 3 是γ-分泌酶调节剂。了解更多

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TC-E 5006

Catalog No. A13217
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Gamma-secretase modulator

TC-E 5006是一种γ-分泌酶调节剂。在体外（EC50 = 390 nM）和体内降低Aβ42水平。了解更多

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gamma-secretase modulator 1

Catalog No. A11425
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Gamma-secretase modulator

gamma-secretase modulator 1是γ-分泌酶调节剂，γ-分泌酶调节剂1可用于阿尔茨海默病。了解更多

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BPN-15606

Catalog No. A18681
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γ-secretase modulator

BPN-15606 is a highly potent, orally active γ-secretase modulator (GSM), attenuates the production of Aβ42 and Aβ40 by SHSY5Y neuroblastoma cells with IC50 values of 7 nM and 17nM, respectively. 了解更多

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NGP-555

Catalog No. A17051
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γ-Secretase Modulator

NGP-555是一种γ-分泌酶调节剂，具有选择性机制，可减少Abeta 42，同时提高较短的Abeta形式，例如Abeta 37和38。了解更多

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NS11394

Catalog No. A21425
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GABA(A) receptor modulator

NS11394 is a potent and subtype-selective GABA(A) receptor-positive modulator; possesses a functional efficacy selectivity profile of alpha(5) > alpha(3) > alpha(2) > alpha(1) at GABA(A) alpha subunit-containing receptors. 了解更多

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CTP354

Catalog No. A15939
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GABA(A) modulator

CTP354是一种新型的氘化亚型选择性GABA（A）调节剂。了解更多

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Basmisanil

Catalog No. A21321
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GABAAα5 modulator

Basmisanil is a highly selective GABAAα5 negative allosteric modulator. 了解更多

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Lorediplon

Catalog No. A13449
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GABAA receptor modulator

Lorediplon 是一种新型的非苯二氮卓类催眠药，作为GABAA受体调节剂。了解更多

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Indiplon

Catalog No. A13769
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GABAA receptor modulator

Indiplon是吡唑并嘧啶，可作为GABAA受体的高亲和力正变构调节剂，以剂量依赖和可逆的方式增强GABA活化的氯离子电流。了解更多

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GLYX-13 (Rapastinel)

Catalog No. A13576
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NMDAR modulator

GLYX-13 (Rapastinel)是NMDA受体甘氨酸位点的选择性弱部分激动剂。了解更多

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GNE 0723

Catalog No. A12757
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NMDAR modulator

GNE 0723 is a brain permeable positive allosteric modulator of NMDAR, with an EC50 of 21 nM for GluN2A, 7.4 and 6.2 μM for GluN2C and GluN2D, respectively. 了解更多

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MK7622

Catalog No. A12835
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M1 调节剂

MK7622是毒蕈碱M1受体阳性变构调节剂。了解更多

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(Rac)-VU 6008667

Catalog No. A21939
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mAChR M5 negative allosteric modulator

(Rac)-VU 6008667 is a selective negative allosteric modulator of muscarinic acetylcholine receptor subtype 5 (M5 NAM) (IC50=1.8 μM, pIC50= 5.75), has high CNS penetration. 了解更多

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Rapacuronium bromide

Catalog No. A21119
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mAChR modulator

Rapacuronium bromide is an allosteric modulator of muscarinic acetylcholine receptor (mAChR). 了解更多

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A-867744

Catalog No. A11290
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modulator of α7 nAChRs

A-867744是α7烟碱乙酰胆碱受体的新型正变构调节剂。了解更多

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(-)-(S)-B-973B

Catalog No. A18761
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α7 nAChR modulator

-)-(S)-B-973B is a potent allosteric agonist and positive allosteric modulator of α7 nAChR, with antinociceptive activity. 了解更多

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BNC375

Catalog No. A18503
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α7 nAChR Modulator

BNC375 is a Potent, Selective, and Orally Available Type I Positive Allosteric Modulator of α7 nAChRs. 了解更多

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CCMI

Catalog No. A21534
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α7 nAChR-positive allosteric modulator

CCMI is a potent and selective α7 nAChR-positive allosteric modulator, does not bind to or activate α7 nAChRs via the orthosteric site, and causes significant positive modulation of agonist-induced currents at α7 nAChRs. 了解更多

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PNU-120596

Catalog No. A11203
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Nicotinic (α7) Receptor Modulator

PNU-120596是α7神经元烟碱型乙酰胆碱受体的正变构调节剂。了解更多

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Tebanicline hydrochloride

Catalog No. A21918
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nAChR modulator

Tebanicline hydrochloride (ABT594 hydrochloride) is a nAChR modulator with potent, orally effective analgesic activity. 了解更多

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GW791343 trihydrochloride

Catalog No. A21204
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P2X7 allosteric modulator

GW791343 3Hcl is a P2X7 allosteric modulator; exhibits species-specific activity and acts as a negative allosteric modulator of human P2X7 (pIC50 = 6.9 - 7.2). 了解更多

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GW791343 HCl

Catalog No. A11107
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P2X7 modulator

GW791343 HCl充当人P2X7的负变构调节剂（pIC50 = 6.9-7.2）和大鼠P2X7的正变构调节剂。了解更多

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溶液配制计算器

分子量计算器

稀释计算器

摩尔浓度计算器

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